1lo1: Difference between revisions

No edit summary
No edit summary
 
(3 intermediate revisions by the same user not shown)
Line 1: Line 1:


==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
==ESTROGEN RELATED RECEPTOR 2 DNA BINDING DOMAIN IN COMPLEX WITH DNA==
<StructureSection load='1lo1' size='340' side='right' caption='[[1lo1]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1lo1' size='340' side='right'caption='[[1lo1]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1lo1]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1LO1 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1LO1 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">hERR2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [http://pdbe.org/1lo1 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [http://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1lo1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1lo1 OCA], [https://pdbe.org/1lo1 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1lo1 RCSB], [https://www.ebi.ac.uk/pdbsum/1lo1 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1lo1 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[http://omim.org/entry/608565 608565]]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>
[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN] Defects in ESRRB are the cause of deafness autosomal recessive type 35 (DFNB35) [MIM:[https://omim.org/entry/608565 608565]. DFNB35 is a form of sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.<ref>PMID:18179891</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN]] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>
[https://www.uniprot.org/uniprot/ERR2_HUMAN ERR2_HUMAN] Nuclear receptor, may regulate ESR1 transcriptional activity.<ref>PMID:19755138</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Line 31: Line 31:
</div>
</div>
<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1lo1" style="background-color:#fffaf0;"></div>
==See Also==
*[[Estrogen-related receptor 3D structures|Estrogen-related receptor 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Dyson, H J]]
[[Category: Large Structures]]
[[Category: Evans, R M]]
[[Category: Dyson HJ]]
[[Category: Gearhart, M D]]
[[Category: Evans RM]]
[[Category: Holmbeck, S M.A]]
[[Category: Gearhart MD]]
[[Category: Wright, P E]]
[[Category: Holmbeck SMA]]
[[Category: Dna binding domain]]
[[Category: Wright PE]]
[[Category: Estrogen related receptor 2]]
[[Category: Herr2]]
[[Category: Hormone nuclear receptor]]
[[Category: Hormone-growth factor receptor-dna complex]]

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA