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==Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain==
==Solution Structure of the Mouse Prohormone Convertase 1 Pro-Domain==
<StructureSection load='1kn6' size='340' side='right' caption='[[1kn6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1kn6' size='340' side='right'caption='[[1kn6]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kn6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Lk3_transgenic_mice Lk3 transgenic mice]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KN6 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kn6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KN6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KN6 FirstGlance]. <br>
</td></tr><tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Proprotein_convertase_1 Proprotein convertase 1], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.93 3.4.21.93] </span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn6 OCA], [http://pdbe.org/1kn6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kn6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kn6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kn6 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kn6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kn6 OCA], [https://pdbe.org/1kn6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kn6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kn6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kn6 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/NEC1_MOUSE NEC1_MOUSE]] Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.  
[https://www.uniprot.org/uniprot/NEC1_MOUSE NEC1_MOUSE] Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin and insulin.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Lk3 transgenic mice]]
[[Category: Large Structures]]
[[Category: Proprotein convertase 1]]
[[Category: Mus musculus]]
[[Category: Bryan, P N]]
[[Category: Bryan PN]]
[[Category: Orban, J]]
[[Category: Orban J]]
[[Category: Sari, N]]
[[Category: Sari N]]
[[Category: Tangrea, M A]]
[[Category: Tangrea MA]]
[[Category: Beta-alpha-beta-beta-alpha-beta]]
[[Category: Hydrolase]]

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