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==Solution structure of the lambda integrase amino-terminal domain==
==Solution structure of the lambda integrase amino-terminal domain==
<StructureSection load='1kjk' size='340' side='right' caption='[[1kjk]], [[NMR_Ensembles_of_Models | 25 NMR models]]' scene=''>
<StructureSection load='1kjk' size='340' side='right'caption='[[1kjk]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1kjk]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Enterobacteria_phage_lambda Enterobacteria phage lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJK OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KJK FirstGlance]. <br>
<table><tr><td colspan='2'>[[1kjk]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_virus_Lambda Escherichia virus Lambda]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KJK OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KJK FirstGlance]. <br>
</td></tr><tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kjk OCA], [http://www.rcsb.org/pdb/explore.do?structureId=1kjk RCSB], [http://www.ebi.ac.uk/pdbsum/1kjk PDBsum]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<table>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kjk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kjk OCA], [https://pdbe.org/1kjk PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kjk RCSB], [https://www.ebi.ac.uk/pdbsum/1kjk PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kjk ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/VINT_LAMBD VINT_LAMBD] Integrase is necessary for integration of the phage into the host genome by site-specific recombination. In conjunction with excisionase, integrase is also necessary for excision of the prophage from the host genome.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kjk_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/kj/1kjk_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1kjk ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 1kjk" style="background-color:#fffaf0;"></div>


==See Also==
==See Also==
*[[Phage integrase|Phage integrase]]
*[[Retroviral integrase 3D structures|Retroviral integrase 3D structures]]
*[[Resolvase|Resolvase]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Enterobacteria phage lambda]]
[[Category: Escherichia virus Lambda]]
[[Category: Clubb, R T.]]
[[Category: Large Structures]]
[[Category: Landy, A.]]
[[Category: Clubb RT]]
[[Category: Sarkar, D.]]
[[Category: Landy A]]
[[Category: Wojciak, J M.]]
[[Category: Sarkar D]]
[[Category: Dna recombination]]
[[Category: Wojciak JM]]
[[Category: Dna-binding domain]]
[[Category: Integrase]]
[[Category: Three-stranded beta-sheet]]
[[Category: Viral protein]]

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