1kd6: Difference between revisions

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OCA

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 ==Solution structure of the eukaryotic pore-forming cytolysin equinatoxin II==
-<StructureSection load='1kd6' size='340' side='right'caption='[[1kd6]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
+<StructureSection load='1kd6' size='340' side='right'caption='[[1kd6]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1kd6]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Acteq Acteq]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KD6 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1KD6 FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1kd6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Actinia_equina Actinia equina]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1KD6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1KD6 FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1kd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kd6 OCA], [http://pdbe.org/1kd6 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1kd6 RCSB], [http://www.ebi.ac.uk/pdbsum/1kd6 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1kd6 ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1kd6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1kd6 OCA], [https://pdbe.org/1kd6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1kd6 RCSB], [https://www.ebi.ac.uk/pdbsum/1kd6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1kd6 ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/ACTP2_ACTEQ ACTP2_ACTEQ]] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.
+[https://www.uniprot.org/uniprot/ACTP2_ACTEQ ACTP2_ACTEQ] Pore-forming protein that forms cations-selective hydrophilic pores of around 1 nm and causes cardiac stimulation and hemolysis. Pore formation is a multi-step process that involves specific recognition of membrane sphingomyelin (but neither cholesterol nor phosphatidylcholine) using aromatic rich region and adjacent phosphocholine (POC) binding site, firm binding to the membrane (mainly driven by hydrophobic interactions) accompanied by the transfer of the N-terminal region to the lipid-water interface and finally pore formation after oligomerization of several monomers. Cytolytic effects include red blood cells hemolysis, platelet aggregation and lysis, cytotoxic and cytostatic effects on fibroblasts. Lethality in mammals has been ascribed to severe vasospasm of coronary vessels, cardiac arrhythmia, and inotropic effects.
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
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 __TOC__
 </StructureSection>
-[[Category: Acteq]]
+[[Category: Actinia equina]]
 [[Category: Large Structures]]
-[[Category: Anderluh, G]]
+[[Category: Anderluh G]]
-[[Category: Hansen, P E]]
+[[Category: Hansen PE]]
-[[Category: Hinds, M G]]
+[[Category: Hinds MG]]
-[[Category: Norton, R S]]
+[[Category: Norton RS]]
-[[Category: Zhang, W]]
+[[Category: Zhang W]]
-[[Category: Beta sandwich]]
-[[Category: Cytolysin]]
-[[Category: Membrane protein]]
-[[Category: Pore formation]]
-[[Category: Sea anemone]]
-[[Category: Toxin]]