1k9c: Difference between revisions

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==Solution Structure of Calreticulin P-domain subdomain (residues 189-261)==
==Solution Structure of Calreticulin P-domain subdomain (residues 189-261)==
<StructureSection load='1k9c' size='340' side='right' caption='[[1k9c]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1k9c' size='340' side='right'caption='[[1k9c]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1k9c]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9C OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1K9C FirstGlance]. <br>
<table><tr><td colspan='2'>[[1k9c]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1K9C OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1K9C FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1hhn|1hhn]], [[1k91|1k91]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1k9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9c OCA], [http://pdbe.org/1k9c PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1k9c RCSB], [http://www.ebi.ac.uk/pdbsum/1k9c PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1k9c FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1k9c OCA], [https://pdbe.org/1k9c PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1k9c RCSB], [https://www.ebi.ac.uk/pdbsum/1k9c PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1k9c ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/CALR_RAT CALR_RAT]] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).  
[https://www.uniprot.org/uniprot/CALR_RAT CALR_RAT] Calcium-binding chaperone that promotes folding, oligomeric assembly and quality control in the endoplasmic reticulum (ER) via the calreticulin/calnexin cycle. This lectin interacts transiently with almost all of the monoglucosylated glycoproteins that are synthesized in the ER. Interacts with the DNA-binding domain of NR3C1 and mediates its nuclear export. Involved in maternal gene expression regulation. May participate in oocyte maturation via the regulation of calcium homeostasis (By similarity).
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k9c_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/k9/1k9c_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
   </jmolCheckbox>
   </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1k9c ConSurf].
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<div class="pdbe-citations 1k9c" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1k9c" style="background-color:#fffaf0;"></div>
==See Also==
*[[Calreticulin 3D structures|Calreticulin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Bettendorff, P]]
[[Category: Rattus norvegicus]]
[[Category: Braun, D]]
[[Category: Bettendorff P]]
[[Category: Ellgaard, L]]
[[Category: Braun D]]
[[Category: Fiorito, F]]
[[Category: Ellgaard L]]
[[Category: Guntert, P]]
[[Category: Fiorito F]]
[[Category: Helenius, A]]
[[Category: Guntert P]]
[[Category: Herrmann, T]]
[[Category: Helenius A]]
[[Category: Wuthrich, K]]
[[Category: Herrmann T]]
[[Category: Hairpin]]
[[Category: Wuthrich K]]
[[Category: Metal transport]]

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