1i6z: Difference between revisions
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==BAG DOMAIN OF BAG1 COCHAPERONE== | ==BAG DOMAIN OF BAG1 COCHAPERONE== | ||
<StructureSection load='1i6z' size='340' side='right' caption='[[1i6z | <StructureSection load='1i6z' size='340' side='right'caption='[[1i6z]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1i6z]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1i6z]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1I6Z OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1I6Z FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1i6z FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1i6z OCA], [https://pdbe.org/1i6z PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1i6z RCSB], [https://www.ebi.ac.uk/pdbsum/1i6z PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1i6z ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/BAG1_MOUSE BAG1_MOUSE] Inhibits the chaperone activity of HSP70/HSC70 by promoting substrate release. Inhibits the pro-apoptotic function of PPP1R15A, and has anti-apoptotic activity. Markedly increases the anti-cell death function of BCL2 induced by various stimuli.<ref>PMID:9873016</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
Check<jmol> | Check<jmol> | ||
<jmolCheckbox> | <jmolCheckbox> | ||
<scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/1i6z_consurf.spt"</scriptWhenChecked> | <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/i6/1i6z_consurf.spt"</scriptWhenChecked> | ||
<scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked> | ||
<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1i6z ConSurf]. | ||
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
<div class="pdbe-citations 1i6z" style="background-color:#fffaf0;"></div> | |||
==See Also== | ==See Also== | ||
*[[BAG | *[[BAG family proteins 3D structures|BAG family proteins 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | [[Category: Mus musculus]] | ||
[[Category: Briknarova | [[Category: Briknarova K]] | ||
[[Category: Brive | [[Category: Brive L]] | ||
[[Category: Cabezas | [[Category: Cabezas E]] | ||
[[Category: Ely | [[Category: Ely KR]] | ||
[[Category: Havert | [[Category: Havert ML]] | ||
[[Category: Homma | [[Category: Homma S]] | ||
[[Category: Hoyt | [[Category: Hoyt DW]] | ||
[[Category: Knee | [[Category: Knee DA]] | ||
[[Category: Llinas | [[Category: Llinas M]] | ||
[[Category: Reed | [[Category: Reed JC]] | ||
[[Category: Satterthwait | [[Category: Satterthwait AC]] | ||
[[Category: Stuart | [[Category: Stuart J]] | ||
[[Category: Takayama | [[Category: Takayama S]] | ||
[[Category: Velasco | [[Category: Velasco J]] | ||