1hnr: Difference between revisions

<StructureSection load='1hnr' size='340' side='right'caption='[[1hnr]]' scene=''>

<table><tr><td colspan='2'>[[1hnr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1HNR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1HNR FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1hnr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1hnr OCA], [https://pdbe.org/1hnr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1hnr RCSB], [https://www.ebi.ac.uk/pdbsum/1hnr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1hnr ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/HNS_ECOLI HNS_ECOLI] A DNA-binding protein implicated in transcriptional repression (silencing) as well as in bacterial chromosome organization. H-NS binds tightly to AT-rich dsDNA, increases its thermal stability and inhibits transcription. Also binds to ssDNA and RNA but with a much lower affinity. H-NS has possible histone-like function. May be a global transcriptional regulator through its ability to bind to curved DNA sequences, which are found in regions upstream of a certain subset of promoters. Plays a role in the thermal control of pili and adhesive curli fimbriae production, by inducing transcription of csgD. Represses the CRISPR-cas promoters, permits only weak transcription of the crRNA precursor; its role is antagonized by LeuO. Subject to transcriptional auto-repression. Binds preferentially to the upstream region of its own gene recognizing two segments of DNA on both sides of a bend centered around -150.<ref>PMID:7934818</ref> <ref>PMID:11031114</ref> <ref>PMID:17010156</ref> <ref>PMID:20659289</ref>  

     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/hn/1hnr_consurf.spt"</scriptWhenChecked>

[[Category: Escherichia coli]]

[[Category: Large Structures]]

[[Category: Ieda R]]

[[Category: Iwaki T]]

[[Category: Kuboniwa H]]

[[Category: Kurumizaka H]]

[[Category: Mizuno T]]

[[Category: Morikawa S]]

[[Category: Nakamura H]]

[[Category: Shindo H]]

[[Category: Ueguchi C]]