1ghu: Difference between revisions

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OCA

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 ==NMR solution structure of growth factor receptor-bound protein 2 (GRB2) SH2 domain, 24 structures==
-<StructureSection load='1ghu' size='340' side='right' caption='[[1ghu]], [[NMR_Ensembles_of_Models | 24 NMR models]]' scene=''>
+<StructureSection load='1ghu' size='340' side='right'caption='[[1ghu]]' scene=''>
 == Structural highlights ==
-<table><tr><td colspan='2'>[[1ghu]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1GHU FirstGlance]. <br>
+<table><tr><td colspan='2'>[[1ghu]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1GHU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1GHU FirstGlance]. <br>
-</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1ghu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ghu OCA], [http://pdbe.org/1ghu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1ghu RCSB], [http://www.ebi.ac.uk/pdbsum/1ghu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1ghu ProSAT]</span></td></tr>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ghu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ghu OCA], [https://pdbe.org/1ghu PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ghu RCSB], [https://www.ebi.ac.uk/pdbsum/1ghu PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ghu ProSAT]</span></td></tr>
 </table>
 == Function ==
-[[http://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN]] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>   Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
+[https://www.uniprot.org/uniprot/GRB2_HUMAN GRB2_HUMAN] Adapter protein that provides a critical link between cell surface growth factor receptors and the Ras signaling pathway.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>   Isoform 2 does not bind to phosphorylated epidermal growth factor receptor (EGFR) but inhibits EGF-induced transactivation of a RAS-responsive element. Isoform 2 acts as a dominant negative protein over GRB2 and by suppressing proliferative signals, may trigger active programmed cell death.<ref>PMID:1322798</ref> <ref>PMID:8178156</ref> <ref>PMID:19815557</ref>
 == Evolutionary Conservation ==
 [[Image:Consurf_key_small.gif|200px|right]]
 Check<jmol>
    <jmolCheckbox>
-     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/1ghu_consurf.spt"</scriptWhenChecked>
+     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/gh/1ghu_consurf.spt"</scriptWhenChecked>
      <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
      <text>to colour the structure by Evolutionary Conservation</text>
@@ Line 29: / Line 30: @@
 ==See Also==
-*[[Growth factor receptor-bound protein|Growth factor receptor-bound protein]]
+*[[Growth factor receptor-bound proteins 3D structures|Growth factor receptor-bound proteins 3D structures]]
 == References ==
 <references/>
 __TOC__
 </StructureSection>
-[[Category: Mcconnell, P]]
+[[Category: Homo sapiens]]
-[[Category: Mueller, W T]]
+[[Category: Large Structures]]
-[[Category: Saltiel, A R]]
+[[Category: Mcconnell P]]
-[[Category: Thanabal, V]]
+[[Category: Mueller WT]]
-[[Category: Thornton, K H]]
+[[Category: Saltiel AR]]
-[[Category: Zhu, G]]
+[[Category: Thanabal V]]
-[[Category: Grb2]]
+[[Category: Thornton KH]]
-[[Category: Sh2]]
+[[Category: Zhu G]]
-[[Category: Src homology 2 domain]]