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[[Image:1dp3.jpg|left|200px]]


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==SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE TRAM PROTEIN==
The line below this paragraph, containing "STRUCTURE_1dp3", creates the "Structure Box" on the page.
<StructureSection load='1dp3' size='340' side='right'caption='[[1dp3]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1dp3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DP3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1DP3 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1dp3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1dp3 OCA], [https://pdbe.org/1dp3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1dp3 RCSB], [https://www.ebi.ac.uk/pdbsum/1dp3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1dp3 ProSAT]</span></td></tr>
{{STRUCTURE_1dp3| PDB=1dp3 |  SCENE= }}
</table>
 
== Function ==
'''SOLUTION STRUCTURE OF THE DNA BINDING DOMAIN OF THE TRAM PROTEIN'''
[https://www.uniprot.org/uniprot/TRAM2_ECOLX TRAM2_ECOLX] Conjugative DNA transfer (CDT) is the unidirectional transfer of ssDNA plasmid from a donor to a recipient cell. It is the central mechanism by which antibiotic resistance and virulence factors are propagated in bacterial populations. Part of the relaxosome, which facilitates a site- and strand-specific cut in the origin of transfer by TraI, at the nic site. Probably autoregulates its own expression. Plasmid specificity is conferred by the TraD-TraM pair (By similarity).
 
== Evolutionary Conservation ==
 
[[Image:Consurf_key_small.gif|200px|right]]
==Overview==
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/dp/1dp3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1dp3 ConSurf].
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
The solution structure of the DNA-binding domain of the TraM protein, an essential component of the DNA transfer machinery of the conjugative resistance plasmid R1, is presented. The structure has been determined using homonuclear 2-dimensional NMR spectroscopy as well as 15N labeled heteronuclear 2- and 3-dimensional NMR spectroscopy. It turns out that the solution structure of the DNA binding domain of the TraM protein is globular and dominantly helical. The very first amino acids of the N-terminus are unstructured.
The solution structure of the DNA-binding domain of the TraM protein, an essential component of the DNA transfer machinery of the conjugative resistance plasmid R1, is presented. The structure has been determined using homonuclear 2-dimensional NMR spectroscopy as well as 15N labeled heteronuclear 2- and 3-dimensional NMR spectroscopy. It turns out that the solution structure of the DNA binding domain of the TraM protein is globular and dominantly helical. The very first amino acids of the N-terminus are unstructured.


==About this Structure==
Solution structure of the DNA-binding domain of TraM.,Stockner T, Plugariu C, Koraimann G, Hogenauer G, Bermel W, Prytulla S, Sterk H Biochemistry. 2001 Mar 20;40(11):3370-7. PMID:11258958<ref>PMID:11258958</ref>
1DP3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1DP3 OCA].


==Reference==
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
Solution structure of the DNA-binding domain of TraM., Stockner T, Plugariu C, Koraimann G, Hogenauer G, Bermel W, Prytulla S, Sterk H, Biochemistry. 2001 Mar 20;40(11):3370-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/11258958 11258958]
</div>
<div class="pdbe-citations 1dp3" style="background-color:#fffaf0;"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Bermel, W.]]
[[Category: Bermel W]]
[[Category: Hoegenauer, G.]]
[[Category: Hoegenauer G]]
[[Category: Koraimann, G.]]
[[Category: Koraimann G]]
[[Category: Plugariu, C.]]
[[Category: Plugariu C]]
[[Category: Prytulla, S.]]
[[Category: Prytulla S]]
[[Category: Sterk, H.]]
[[Category: Sterk H]]
[[Category: Stockner, T.]]
[[Category: Stockner T]]
[[Category: Helix-loop-helix]]
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