1cww: Difference between revisions

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-{{Seed}}
-[[Image:1cww.png|left|200px]]
-<!--
+==SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1==
-The line below this paragraph, containing "STRUCTURE_1cww", creates the "Structure Box" on the page.
+<StructureSection load='1cww' size='340' side='right'caption='[[1cww]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1cww]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1CWW FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1cww FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1cww OCA], [https://pdbe.org/1cww PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1cww RCSB], [https://www.ebi.ac.uk/pdbsum/1cww PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1cww ProSAT]</span></td></tr>
-{{STRUCTURE_1cww|  PDB=1cww  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/APAF_HUMAN APAF_HUMAN] Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis.<ref>PMID:10393175</ref> <ref>PMID:12804598</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/cw/1cww_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1cww ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Activation of procaspase-9, a key component of the apoptosis mechanism, requires the interaction of its caspase recruitment domain (CARD) with the CARD in the adaptor protein Apaf-1. Using nuclear magnetic resonance spectroscopy and mutagenesis we have determined the structure of the CARD from Apaf-1 and the residues important for binding the CARD in procaspase-9. Apaf-1's CARD contains seven short alpha-helices with the core six helices arranged in an antiparallel manner. Residues in helix 2 have a central role in mediating interaction with procaspase-9 CARD. This interaction surface is distinct from that proposed based on the structure of the CARD from RAIDD, but is coincident with that of the structurally similar FADD death effector domain and the Apaf-1 CARD interface identified by crystallographic studies.
-===SOLUTION STRUCTURE OF THE CASPASE RECRUITMENT DOMAIN (CARD) FROM APAF-1===
+Solution structure and mutagenesis of the caspase recruitment domain (CARD) from Apaf-1.,Day CL, Dupont C, Lackmann M, Vaux DL, Hinds MG Cell Death Differ. 1999 Nov;6(11):1125-32. PMID:10578182<ref>PMID:10578182</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 1cww" style="background-color:#fffaf0;"></div>
-<!--
+==See Also==
-The line below this paragraph, {{ABSTRACT_PUBMED_10578182}}, adds the Publication Abstract to the page
+*[[Apoptotic protease-activating factor-1 3D structures|Apoptotic protease-activating factor-1 3D structures]]
-(as it appears on PubMed at http://www.pubmed.gov), where 10578182 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_10578182}}
+__TOC__
+</StructureSection>
-==About this Structure==
-CWW is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1CWW OCA].
-==Reference==
-<ref group="xtra">PMID:10578182</ref><references group="xtra"/>
 [[Category: Homo sapiens]]
-[[Category: Day, C L.]]
+[[Category: Large Structures]]
-[[Category: Dupont, C.]]
+[[Category: Day CL]]
-[[Category: Hinds, M G.]]
+[[Category: Dupont C]]
-[[Category: Lackmann, M.]]
+[[Category: Hinds MG]]
-[[Category: Vaux, D L.]]
+[[Category: Lackmann M]]
-[[Category: Helical bundle]]
+[[Category: Vaux DL]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 16:38:36 2009''