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==STRUCTURE AND INTERACTION SITE OF THE REGULATORY DOMAIN OF TROPONIN-C WHEN COMPLEXED WITH THE 96-148 REGION OF TROPONIN-I, NMR, 29 STRUCTURES==
==STRUCTURE AND INTERACTION SITE OF THE REGULATORY DOMAIN OF TROPONIN-C WHEN COMPLEXED WITH THE 96-148 REGION OF TROPONIN-I, NMR, 29 STRUCTURES==
<StructureSection load='1blq' size='340' side='right' caption='[[1blq]], [[NMR_Ensembles_of_Models | 29 NMR models]]' scene=''>
<StructureSection load='1blq' size='340' side='right'caption='[[1blq]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1blq]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BLQ OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1BLQ FirstGlance]. <br>
<table><tr><td colspan='2'>[[1blq]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Gallus_gallus Gallus gallus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1BLQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1BLQ FirstGlance]. <br>
</td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1blq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1blq OCA], [http://pdbe.org/1blq PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1blq RCSB], [http://www.ebi.ac.uk/pdbsum/1blq PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1blq ProSAT]</span></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1blq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1blq OCA], [https://pdbe.org/1blq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1blq RCSB], [https://www.ebi.ac.uk/pdbsum/1blq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1blq ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TNNC2_CHICK TNNC2_CHICK]] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.  
[https://www.uniprot.org/uniprot/TNNC2_CHICK TNNC2_CHICK] Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1blq_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/bl/1blq_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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==See Also==
==See Also==
*[[Troponin|Troponin]]
*[[Troponin 3D structures|Troponin 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Corson, D C]]
[[Category: Gallus gallus]]
[[Category: Gagne, S M]]
[[Category: Large Structures]]
[[Category: Mckay, R T]]
[[Category: Corson DC]]
[[Category: Pearlstone, J R]]
[[Category: Gagne SM]]
[[Category: Smillie, L B]]
[[Category: Mckay RT]]
[[Category: Sykes, B D]]
[[Category: Pearlstone JR]]
[[Category: Calcium-binding]]
[[Category: Smillie LB]]
[[Category: Calcium-binding protein]]
[[Category: Sykes BD]]
[[Category: Contraction]]
[[Category: Regulation]]
[[Category: Skeletal muscle]]
[[Category: Troponin c]]

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