1ap0: Difference between revisions

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-[[Image:1ap0.gif|left|200px]]
- {{Structure
+==STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES==
-|PDB= 1ap0 |SIZE=350|CAPTION= <scene name='initialview01'>1ap0</scene>
+<StructureSection load='1ap0' size='340' side='right'caption='[[1ap0]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1ap0]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP0 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AP0 FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ap0 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ap0 OCA], [https://pdbe.org/1ap0 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ap0 RCSB], [https://www.ebi.ac.uk/pdbsum/1ap0 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ap0 ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
-'''STRUCTURE OF THE CHROMATIN BINDING (CHROMO) DOMAIN FROM MOUSE MODIFIER PROTEIN 1, NMR, 26 STRUCTURES'''
+[https://www.uniprot.org/uniprot/CBX1_MOUSE CBX1_MOUSE] Component of heterochromatin. Recognizes and binds histone H3 tails methylated at 'Lys-9', leading to epigenetic repression. Interaction with lamin B receptor (LBR) can contribute to the association of the heterochromatin with the inner nuclear membrane.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==Overview==
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ap/1ap0_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ap0 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
 The structure of a chromatin binding domain from mouse chromatin modifier protein 1 (MoMOD1) was determined using nuclear magnetic resonance (NMR) spectroscopy. The protein consists of an N-terminal three-stranded anti-parallel beta-sheet which folds against a C-terminal alpha-helix. The structure reveals an unexpected homology to two archaebacterial DNA binding proteins which are also involved in chromatin structure. Structural comparisons suggest that chromo domains, of which more than 40 are now known, act as protein interaction motifs and that the MoMOD1 protein acts as an adaptor mediating interactions between different proteins.
-==About this Structure==
+Structure of the chromatin binding (chromo) domain from mouse modifier protein 1.,Ball LJ, Murzina NV, Broadhurst RW, Raine AR, Archer SJ, Stott FJ, Murzin AG, Singh PB, Domaille PJ, Laue ED EMBO J. 1997 May 1;16(9):2473-81. PMID:9171360<ref>PMID:9171360</ref>
-AP0 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AP0 OCA].
-==Reference==
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-Structure of the chromatin binding (chromo) domain from mouse modifier protein 1., Ball LJ, Murzina NV, Broadhurst RW, Raine AR, Archer SJ, Stott FJ, Murzin AG, Singh PB, Domaille PJ, Laue ED, EMBO J. 1997 May 1;16(9):2473-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/9171360 9171360]
+</div>
+<div class="pdbe-citations 1ap0" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Mus musculus]]
-[[Category: Single protein]]
+[[Category: Archer SJ]]
-[[Category: Archer, S J.]]
+[[Category: Ball LJ]]
-[[Category: Ball, L J.]]
+[[Category: Broadhurst RW]]
-[[Category: Broadhurst, R W.]]
+[[Category: Domaille PJ]]
-[[Category: Domaille, P J.]]
+[[Category: Laue ED]]
-[[Category: Laue, E D.]]
+[[Category: Murzin AG]]
-[[Category: Murzin, A G.]]
+[[Category: Murzina NV]]
-[[Category: Murzina, N V.]]
+[[Category: Raine ARC]]
-[[Category: Raine, A R.C.]]
+[[Category: Singh PB]]
-[[Category: Singh, P B.]]
+[[Category: Stott FJ]]
-[[Category: Stott, F J.]]
-[[Category: alpha+beta]]
-[[Category: chromatin-binding]]
-[[Category: protein interaction motif]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 10:00:31 2008''