1ak7: Difference between revisions

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-{{Seed}}
-[[Image:1ak7.png|left|200px]]
-<!--
+==DESTRIN, NMR, 20 STRUCTURES==
-The line below this paragraph, containing "STRUCTURE_1ak7", creates the "Structure Box" on the page.
+<StructureSection load='1ak7' size='340' side='right'caption='[[1ak7]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1ak7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1AK7 FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1ak7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1ak7 OCA], [https://pdbe.org/1ak7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1ak7 RCSB], [https://www.ebi.ac.uk/pdbsum/1ak7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1ak7 ProSAT]</span></td></tr>
-{{STRUCTURE_1ak7|  PDB=1ak7  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/DEST_PIG DEST_PIG] Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ak/1ak7_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1ak7 ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Destrin is an isoprotein of cofilin that regulates actin cytoskeleton in various eukaryotes. We determined the tertiary structure of destrin by triple-resonance multidimensional nuclear magnetic resonance. In spite of there being no significant amino acid sequence homology, we found that the folding of destrin was strikingly similar to that of repeated segments in the gelsolin family, which resulted in a new protein fold group. Sequential dissimilarity of the actin-binding helix of destrin to that of gelsolin explains the Ca2+-independent actin-binding of destrin. Possible mechanisms of phosphorylation-sensitive phosphoinositide-competitive actin binding, of pH-dependent filament severing, and of nuclear translocation with actin in response to stresses, are discussed on the basis of the tertiary structure.
-===DESTRIN, NMR, 20 STRUCTURES===
+Tertiary structure of destrin and structural similarity between two actin-regulating protein families.,Hatanaka H, Ogura K, Moriyama K, Ichikawa S, Yahara I, Inagaki F Cell. 1996 Jun 28;85(7):1047-55. PMID:8674111<ref>PMID:8674111</ref>
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-<!--
+</div>
-The line below this paragraph, {{ABSTRACT_PUBMED_8674111}}, adds the Publication Abstract to the page
+<div class="pdbe-citations 1ak7" style="background-color:#fffaf0;"></div>
-(as it appears on PubMed at http://www.pubmed.gov), where 8674111 is the PubMed ID number.
+== References ==
--->
+<references/>
-{{ABSTRACT_PUBMED_8674111}}
+__TOC__
+</StructureSection>
-==About this Structure==
+[[Category: Large Structures]]
-AK7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Sus_scrofa Sus scrofa]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1AK7 OCA].
-==Reference==
-<ref group="xtra">PMID:8674111</ref><references group="xtra"/>
 [[Category: Sus scrofa]]
-[[Category: Hatanaka, H.]]
+[[Category: Hatanaka H]]
-[[Category: Ichikawa, S.]]
+[[Category: Ichikawa S]]
-[[Category: Inagaki, F.]]
+[[Category: Inagaki F]]
-[[Category: Moriyama, K.]]
+[[Category: Moriyama K]]
-[[Category: Ogura, K.]]
+[[Category: Ogura K]]
-[[Category: Yahara, I.]]
+[[Category: Yahara I]]
-[[Category: Actin depolymerization factor]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Wed Feb 18 07:07:19 2009''