1zkh: Difference between revisions

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-[[Image:1zkh.png|left|200px]]
-{{STRUCTURE_1zkh|  PDB=1zkh  |  SCENE=  }}
+==Solution structure of a human ubiquitin-like domain in SF3A1==
+<StructureSection load='1zkh' size='340' side='right'caption='[[1zkh]]' scene=''>
-===Solution structure of a human ubiquitin-like domain in SF3A1===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1zkh]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1ZKH FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1zkh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1zkh OCA], [https://pdbe.org/1zkh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1zkh RCSB], [https://www.ebi.ac.uk/pdbsum/1zkh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1zkh ProSAT]</span></td></tr>
-[[1zkh]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZKH OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/SF3A1_HUMAN SF3A1_HUMAN] Subunit of the splicing factor SF3A required for 'A' complex assembly formed by the stable binding of U2 snRNP to the branchpoint sequence (BPS) in pre-mRNA. Sequence independent binding of SF3A/SF3B complex upstream of the branch site is essential, it may anchor U2 snRNP to the pre-mRNA. May also be involved in the assembly of the 'E' complex.
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/zk/1zkh_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1zkh ConSurf].
+<div style="clear:both"></div>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Large Structures]]
-[[Category: Avvakumov, G V.]]
+[[Category: Arrowsmith CH]]
-[[Category: Dhe-Paganon, S.]]
+[[Category: Avvakumov GV]]
-[[Category: Edwards, A.]]
+[[Category: Dhe-Paganon S]]
-[[Category: Guido, V.]]
+[[Category: Edwards A]]
-[[Category: Lemak, A.]]
+[[Category: Guido V]]
-[[Category: Lukin, J A.]]
+[[Category: Lemak A]]
-[[Category: Mackenzie, F.]]
+[[Category: Lukin JA]]
-[[Category: Newman, E M.]]
+[[Category: Mackenzie F]]
-[[Category: SGC, Structural Genomics Consortium.]]
+[[Category: Newman EM]]
-[[Category: Sundstrom, M.]]
+[[Category: Sundstrom M]]
-[[Category: Xue, S.]]
+[[Category: Xue S]]
-[[Category: Gene regulation]]
-[[Category: Sgc]]
-[[Category: Splicing factor]]
-[[Category: Structural genomic]]
-[[Category: Structural genomics consortium]]
-[[Category: Ubiquitin]]