1yxr: Difference between revisions

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-[[Image:1yxr.gif|left|200px]]
-<!--
+==NMR Structure of VPS4A MIT Domain==
-The line below this paragraph, containing "STRUCTURE_1yxr", creates the "Structure Box" on the page.
+<StructureSection load='1yxr' size='340' side='right'caption='[[1yxr]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1yxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YXR FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxr OCA], [https://pdbe.org/1yxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxr RCSB], [https://www.ebi.ac.uk/pdbsum/1yxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxr ProSAT]</span></td></tr>
-{{STRUCTURE_1yxr|  PDB=1yxr  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/VPS4A_HUMAN VPS4A_HUMAN] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis.<ref>PMID:11563910</ref> <ref>PMID:11595185</ref> <ref>PMID:15075231</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/yx/1yxr_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1yxr ConSurf].
+<div style="clear:both"></div>
-'''NMR Structure of VPS4A MIT Domain'''
+==See Also==
+*[[Vacuolar protein sorting-associated protein 3D structures|Vacuolar protein sorting-associated protein 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-YXR is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXR OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Alam, S.]]
+[[Category: Alam S]]
-[[Category: Gaspar, J.]]
+[[Category: Gaspar J]]
-[[Category: Scott, J A.]]
+[[Category: Scott JA]]
-[[Category: Skalicky, J.]]
+[[Category: Skalicky J]]
-[[Category: Stuchell, M.]]
+[[Category: Stuchell M]]
-[[Category: Sundquist, W I.]]
+[[Category: Sundquist WI]]
-[[Category: Mit domain]]
-[[Category: Vps4]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May  3 16:56:08 2008''