1yxr: Difference between revisions
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==NMR Structure of VPS4A MIT Domain== | ==NMR Structure of VPS4A MIT Domain== | ||
<StructureSection load='1yxr' size='340' side='right'caption='[[1yxr | <StructureSection load='1yxr' size='340' side='right'caption='[[1yxr]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1yxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1yxr]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1YXR OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1YXR FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxr OCA], [https://pdbe.org/1yxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxr RCSB], [https://www.ebi.ac.uk/pdbsum/1yxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxr ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1yxr FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1yxr OCA], [https://pdbe.org/1yxr PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1yxr RCSB], [https://www.ebi.ac.uk/pdbsum/1yxr PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1yxr ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/VPS4A_HUMAN VPS4A_HUMAN] Involved in late steps of the endosomal multivesicular bodies (MVB) pathway. Recognizes membrane-associated ESCRT-III assemblies and catalyzes their disassembly, possibly in combination with membrane fission. Redistributes the ESCRT-III components to the cytoplasm for further rounds of MVB sorting. MVBs contain intraluminal vesicles (ILVs) that are generated by invagination and scission from the limiting membrane of the endosome and mostly are delivered to lysosomes enabling degradation of membrane proteins, such as stimulated growth factor receptors, lysosomal enzymes and lipids. In conjunction with the ESCRT machinery also appears to function in topologically equivalent membrane fission events, such as the terminal stages of cytokinesis and enveloped virus budding (HIV-1 and other lentiviruses). Involved in cytokinesis.<ref>PMID:11563910</ref> <ref>PMID:11595185</ref> <ref>PMID:15075231</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Alam | [[Category: Alam S]] | ||
[[Category: Gaspar | [[Category: Gaspar J]] | ||
[[Category: Scott | [[Category: Scott JA]] | ||
[[Category: Skalicky | [[Category: Skalicky J]] | ||
[[Category: Stuchell | [[Category: Stuchell M]] | ||
[[Category: Sundquist | [[Category: Sundquist WI]] | ||