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==Solution Structure of Escherichia coli TonB-CTD==
==Solution Structure of Escherichia coli TonB-CTD==
<StructureSection load='1xx3' size='340' side='right' caption='[[1xx3]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
<StructureSection load='1xx3' size='340' side='right'caption='[[1xx3]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xx3]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_coli"_migula_1895 "bacillus coli" migula 1895]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XX3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XX3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xx3]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XX3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XX3 FirstGlance]. <br>
</td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">tonB, exbA ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=562 "Bacillus coli" Migula 1895])</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xx3 OCA], [http://pdbe.org/1xx3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xx3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xx3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xx3 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xx3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xx3 OCA], [https://pdbe.org/1xx3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xx3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xx3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xx3 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/TONB_ECOLI TONB_ECOLI]] Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.  
[https://www.uniprot.org/uniprot/TONB_ECOLI TONB_ECOLI] Interacts with outer membrane receptor proteins that carry out high-affinity binding and energy dependent uptake into the periplasmic space of specific substrates such as cobalamin, and various iron compounds (such as iron dicitrate, enterochelin, aerobactin, etc.). In the absence of TonB these receptors bind their substrates but do not carry out active transport. TonB also interacts with some colicins and is involved in the energy-dependent, irreversible steps of bacteriophages phi 80 and T1 infection. It could act to transduce energy from the cytoplasmic membrane to specific energy-requiring processes in the outer membrane, resulting in the release into the periplasm of ligands bound by these outer membrane proteins.
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Bacillus coli migula 1895]]
[[Category: Escherichia coli]]
[[Category: Howard, S P]]
[[Category: Large Structures]]
[[Category: Peacock, R S]]
[[Category: Howard SP]]
[[Category: Price, F D]]
[[Category: Peacock RS]]
[[Category: Vogel, H J]]
[[Category: Price FD]]
[[Category: Weljie, A M]]
[[Category: Vogel HJ]]
[[Category: C-terminal domain]]
[[Category: Weljie AM]]
[[Category: Tonb-ctd]]
[[Category: Transport protein]]

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