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==Crystal structure of Northeast Structural Genomics Target SR156==
==Crystal structure of Northeast Structural Genomics Target SR156==
<StructureSection load='1xm3' size='340' side='right' caption='[[1xm3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
<StructureSection load='1xm3' size='340' side='right'caption='[[1xm3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1xm3]] is a 4 chain structure with sequence from [http://en.wikipedia.org/wiki/"vibrio_subtilis"_ehrenberg_1835 "vibrio subtilis" ehrenberg 1835]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM3 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1XM3 FirstGlance]. <br>
<table><tr><td colspan='2'>[[1xm3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XM3 FirstGlance]. <br>
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">thiG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 "Vibrio subtilis" Ehrenberg 1835])</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1xm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm3 OCA], [http://pdbe.org/1xm3 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1xm3 RCSB], [http://www.ebi.ac.uk/pdbsum/1xm3 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm3 ProSAT], [http://www.topsan.org/Proteins/NESGC/1xm3 TOPSAN]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm3 OCA], [https://pdbe.org/1xm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xm3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm3 ProSAT], [https://www.topsan.org/Proteins/NESGC/1xm3 TOPSAN]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/THIG_BACSU THIG_BACSU]] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.<ref>PMID:14567704</ref>
[https://www.uniprot.org/uniprot/THIG_BACSU THIG_BACSU] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.<ref>PMID:14567704</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Vibrio subtilis ehrenberg 1835]]
[[Category: Bacillus subtilis]]
[[Category: Abashidze, M]]
[[Category: Large Structures]]
[[Category: Acton, T]]
[[Category: Abashidze M]]
[[Category: Forouhar, F]]
[[Category: Acton T]]
[[Category: Hunt, J]]
[[Category: Forouhar F]]
[[Category: Kuzin, A]]
[[Category: Hunt J]]
[[Category: Ma, L]]
[[Category: Kuzin A]]
[[Category: Montelione, G]]
[[Category: Ma L]]
[[Category: Structural genomic]]
[[Category: Montelione G]]
[[Category: Tong, L]]
[[Category: Tong L]]
[[Category: Vorobiev, S]]
[[Category: Vorobiev S]]
[[Category: Xiao, R]]
[[Category: Xiao R]]
[[Category: Biosynthetic protein]]
[[Category: Nesg]]
[[Category: PSI, Protein structure initiative]]

Latest revision as of 10:55, 15 May 2024

Crystal structure of Northeast Structural Genomics Target SR156Crystal structure of Northeast Structural Genomics Target SR156

Structural highlights

1xm3 is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

THIG_BACSU Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. 2003 Oct 28;42(42):12430-8. PMID:14567704 doi:http://dx.doi.org/10.1021/bi034902z

1xm3, resolution 1.80Å

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