1xm3: Difference between revisions

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[[Image:1xm3.jpg|left|200px]]


{{Structure
==Crystal structure of Northeast Structural Genomics Target SR156==
|PDB= 1xm3 |SIZE=350|CAPTION= <scene name='initialview01'>1xm3</scene>, resolution 1.80&Aring;
<StructureSection load='1xm3' size='340' side='right'caption='[[1xm3]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
|SITE=  
== Structural highlights ==
|LIGAND=  
<table><tr><td colspan='2'>[[1xm3]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM3 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1XM3 FirstGlance]. <br>
|ACTIVITY=  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.8&#8491;</td></tr>
|GENE= thiG ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=1423 Bacillus subtilis])
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
}}
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1xm3 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1xm3 OCA], [https://pdbe.org/1xm3 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1xm3 RCSB], [https://www.ebi.ac.uk/pdbsum/1xm3 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1xm3 ProSAT], [https://www.topsan.org/Proteins/NESGC/1xm3 TOPSAN]</span></td></tr>
 
</table>
'''Crystal structure of Northeast Structural Genomics Target SR156'''
== Function ==
 
[https://www.uniprot.org/uniprot/THIG_BACSU THIG_BACSU] Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.<ref>PMID:14567704</ref>
 
== Evolutionary Conservation ==
==About this Structure==
[[Image:Consurf_key_small.gif|200px|right]]
1XM3 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Bacillus_subtilis Bacillus subtilis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1XM3 OCA].  
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/xm/1xm3_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1xm3 ConSurf].
<div style="clear:both"></div>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Bacillus subtilis]]
[[Category: Bacillus subtilis]]
[[Category: Single protein]]
[[Category: Large Structures]]
[[Category: Abashidze, M.]]
[[Category: Abashidze M]]
[[Category: Acton, T.]]
[[Category: Acton T]]
[[Category: Forouhar, F.]]
[[Category: Forouhar F]]
[[Category: Hunt, J.]]
[[Category: Hunt J]]
[[Category: Kuzin, A.]]
[[Category: Kuzin A]]
[[Category: Ma, L.]]
[[Category: Ma L]]
[[Category: Montelione, G.]]
[[Category: Montelione G]]
[[Category: NESG, Northeast Structural Genomics Consortium.]]
[[Category: Tong L]]
[[Category: Tong, L.]]
[[Category: Vorobiev S]]
[[Category: Vorobiev, S.]]
[[Category: Xiao R]]
[[Category: Xiao, R.]]
[[Category: nesg]]
[[Category: northeast structural genomics consortium]]
[[Category: protein structure initiative]]
[[Category: psi]]
[[Category: structural genomic]]
[[Category: x-ray structure]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:11:42 2008''

Latest revision as of 10:55, 15 May 2024

Crystal structure of Northeast Structural Genomics Target SR156Crystal structure of Northeast Structural Genomics Target SR156

Structural highlights

1xm3 is a 4 chain structure with sequence from Bacillus subtilis. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:X-ray diffraction, Resolution 1.8Å
Ligands:
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT, TOPSAN

Function

THIG_BACSU Catalyzes the rearrangement of 1-deoxy-D-xylulose 5-phosphate (DXP) to produce the thiazole phosphate moiety of thiamine. Sulfur is provided by the thiocarboxylate moiety of the carrier protein ThiS. In vitro, sulfur can be provided by H(2)S.[1]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

References

  1. ↑ Park JH, Dorrestein PC, Zhai H, Kinsland C, McLafferty FW, Begley TP. Biosynthesis of the thiazole moiety of thiamin pyrophosphate (vitamin B1). Biochemistry. 2003 Oct 28;42(42):12430-8. PMID:14567704 doi:http://dx.doi.org/10.1021/bi034902z

1xm3, resolution 1.80Å

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