2mxc: Difference between revisions

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-'''Unreleased structure'''
-The entry 2mxc is ON HOLD  until Apr 30 2017
+==Solution structure of the full length sorting nexin 3==
+<StructureSection load='2mxc' size='340' side='right'caption='[[2mxc]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2mxc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MXC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MXC FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mxc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mxc OCA], [https://pdbe.org/2mxc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mxc RCSB], [https://www.ebi.ac.uk/pdbsum/2mxc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mxc ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] MMEP syndrome. The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving SNX3 has been found in patients with syndromic microphthalmia. Translocation t(6;13)(q21;q12).
+== Function ==
+[https://www.uniprot.org/uniprot/SNX3_HUMAN SNX3_HUMAN] Phosphoinositide-binding protein required for multivesicular body formation. Specifically binds phosphatidylinositol 3-phosphate (PtdIns(P3)). Plays a role in protein transport between cellular compartments. Promotes stability and cell surface expression of epithelial sodium channel (ENAC) subunits SCNN1A and SCNN1G (By similarity). Not involved in EGFR degradation.<ref>PMID:11433298</ref> <ref>PMID:18767904</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+Sorting nexins anchor trafficking machines to membranes by binding phospholipids. The paradigm of the superfamily is sorting nexin 3 (SNX3), which localizes to early endosomes by recognizing phosphatidylinositol 3-phosphate (PI3P) to initiate retromer-mediated segregation of cargoes to the trans-Golgi network (TGN). Here we report the solution structure of full length human SNX3, and show that PI3P recognition is accompanied by bilayer insertion of a proximal loop in its extended Phox homology (PX) domain. Phosphoinositide (PIP) binding is completely blocked by cancer-linked phosphorylation of a conserved serine beside the stereospecific PI3P pocket. This "PIP-stop" releases endosomal SNX3 to the cytosol, and reveals how protein kinases control membrane assemblies. It constitutes a widespread regulatory element found across the PX superfamily and throughout evolution including of fungi and plants. This illuminates the mechanism of a biological switch whereby structured PIP sites are phosphorylated to liberate protein machines from organelle surfaces.
-Authors: Lenoir, M.M.L., Rajesh, S.S.R., Gruenberg, J.J.G., Overduin, M.M.O., Kaur, J.J.K.
+Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting.,Lenoir M, Ustunel C, Rajesh S, Kaur J, Moreau D, Gruenberg J, Overduin M Nat Commun. 2018 Mar 8;9(1):993. doi: 10.1038/s41467-018-03370-1. PMID:29520003<ref>PMID:29520003</ref>
-Description: Solution structure of the full length sorting nexin 3
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
-[[Category: Unreleased Structures]]
+</div>
-[[Category: Overduin, M.M.O]]
+<div class="pdbe-citations 2mxc" style="background-color:#fffaf0;"></div>
-[[Category: Rajesh, S.S.R]]
-[[Category: Gruenberg, J.J.G]]
+==See Also==
-[[Category: Kaur, J.J.K]]
+*[[Sorting nexin 3D structures|Sorting nexin 3D structures]]
-[[Category: Lenoir, M.M.L]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Gruenberg JJG]]
+[[Category: Kaur JJK]]
+[[Category: Lenoir MML]]
+[[Category: Overduin MMO]]
+[[Category: Rajesh SSR]]