2mjc: Difference between revisions
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New page: '''Unreleased structure''' The entry 2mjc is ON HOLD Authors: Al-Abdul-Wahid, M., Menade, M., Xie, J., Kozlov, G., Gehring, K. Description: Zn-binding domain of eukaryotic translation ... |
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The | ==Zn-binding domain of eukaryotic translation initiation factor 3, subunit G== | ||
<StructureSection load='2mjc' size='340' side='right'caption='[[2mjc]]' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[2mjc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MJC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MJC FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | |||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mjc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mjc OCA], [https://pdbe.org/2mjc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mjc RCSB], [https://www.ebi.ac.uk/pdbsum/2mjc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mjc ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/EIF3G_HUMAN EIF3G_HUMAN] Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA. | |||
==See Also== | |||
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]] | |||
__TOC__ | |||
</StructureSection> | |||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Al-Abdul-Wahid M]] | |||
[[Category: Gehring K]] | |||
[[Category: Kozlov G]] | |||
[[Category: Menade M]] | |||
[[Category: Xie J]] | |||
Latest revision as of 09:06, 15 May 2024
Zn-binding domain of eukaryotic translation initiation factor 3, subunit GZn-binding domain of eukaryotic translation initiation factor 3, subunit G
Structural highlights
FunctionEIF3G_HUMAN Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. This subunit can bind 18S rRNA. See Also |
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