2mb7: Difference between revisions
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==Solution structure of MBD3 methylcytosine binding domain== | ==Solution structure of MBD3 methylcytosine binding domain== | ||
<StructureSection load='2mb7' size='340' side='right'caption='[[2mb7 | <StructureSection load='2mb7' size='340' side='right'caption='[[2mb7]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2mb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2mb7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2MB7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2MB7 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb7 OCA], [https://pdbe.org/2mb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2mb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mb7 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2mb7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2mb7 OCA], [https://pdbe.org/2mb7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2mb7 RCSB], [https://www.ebi.ac.uk/pdbsum/2mb7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2mb7 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/MBD3_HUMAN MBD3_HUMAN] Acts as transcriptional repressor and plays a role in gene silencing. Does not bind DNA by itself. Recruits histone deacetylases and DNA methyltransferases.<ref>PMID:9774669</ref> <ref>PMID:10947852</ref> <ref>PMID:12124384</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Scarsdale | [[Category: Scarsdale JN]] | ||
[[Category: Williams | [[Category: Williams Jr DC]] | ||