2m5m: Difference between revisions

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-'''Unreleased structure'''
-The entry 2m5m is ON HOLD
+==Atomic-resolution structure of a triplet cross-beta amyloid fibril==
+<SX load='2m5m' size='340' side='right' viewer='molstar' caption='[[2m5m]], [[Resolution|resolution]] 12.20&Aring;' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2m5m]] is a 12 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M5M OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M5M FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy , Hybrid , Solid-state NMR, [[Resolution|Resolution]] 12.2&#8491;</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m5m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m5m OCA], [https://pdbe.org/2m5m PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m5m RCSB], [https://www.ebi.ac.uk/pdbsum/2m5m PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m5m ProSAT]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/TTHY_RAT TTHY_RAT] Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain.<ref>PMID:2309926</ref>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+The cross-beta amyloid form of peptides and proteins represents an archetypal and widely accessible structure consisting of ordered arrays of beta-sheet filaments. These complex aggregates have remarkable chemical and physical properties, and the conversion of normally soluble functional forms of proteins into amyloid structures is linked to many debilitating human diseases, including several common forms of age-related dementia. Despite their importance, however, cross-beta amyloid fibrils have proved to be recalcitrant to detailed structural analysis. By combining structural constraints from a series of experimental techniques spanning five orders of magnitude in length scale--including magic angle spinning nuclear magnetic resonance spectroscopy, X-ray fiber diffraction, cryoelectron microscopy, scanning transmission electron microscopy, and atomic force microscopy--we report the atomic-resolution (0.5 A) structures of three amyloid polymorphs formed by an 11-residue peptide. These structures reveal the details of the packing interactions by which the constituent beta-strands are assembled hierarchically into protofilaments, filaments, and mature fibrils.
-Authors: Fitzpatrick, A.W.P., Debelouchina, G.T., Bayro, M.J., Clare, D.K., Caporini, M.A., Bajaj, V.S., Jaroniec, C.P., Wang, L., Ladizhansky, V., Muller, S., MacPhee, C.E., Waudby, C.A., Mott, H.R., de Simone, A., Knowles, T.P.J., Saibil, H.R., Vendruscolo, M., Orlova, E.V., Griffin, R.G., Dobson, C.M.
+Atomic structure and hierarchical assembly of a cross-beta amyloid fibril.,Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Muller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5468-73. doi:, 10.1073/pnas.1219476110. Epub 2013 Mar 19. PMID:23513222<ref>PMID:23513222</ref>
-Description: Atomic-resolution structure of a triplet cross-beta amyloid fibril
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
+<div class="pdbe-citations 2m5m" style="background-color:#fffaf0;"></div>
+== References ==
+<references/>
+__TOC__
+</SX>
+[[Category: Large Structures]]
+[[Category: Rattus norvegicus]]
+[[Category: Bajaj VS]]
+[[Category: Bayro MJ]]
+[[Category: Caporini MA]]
+[[Category: Clare DK]]
+[[Category: Debelouchina GT]]
+[[Category: Dobson CM]]
+[[Category: Fitzpatrick AWP]]
+[[Category: Griffin RG]]
+[[Category: Jaroniec CP]]
+[[Category: Knowles TPJ]]
+[[Category: Ladizhansky V]]
+[[Category: MacPhee CE]]
+[[Category: Mott HR]]
+[[Category: Muller S]]
+[[Category: Orlova EV]]
+[[Category: Saibil HR]]
+[[Category: Vendruscolo M]]
+[[Category: Wang L]]
+[[Category: Waudby CA]]
+[[Category: De Simone A]]