2m1w: Difference between revisions

<StructureSection load='2m1w' size='340' side='right'caption='[[2m1w]]' scene=''>

<table><tr><td colspan='2'>[[2m1w]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2M1W OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2M1W FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2m1w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2m1w OCA], [https://pdbe.org/2m1w PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2m1w RCSB], [https://www.ebi.ac.uk/pdbsum/2m1w PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2m1w ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/TCAM2_HUMAN TCAM2_HUMAN] Functions as sorting adapter in LPS-TLR4 signaling to regulate the MYD88-independent pathway during the innate immune response to LPS. Physically bridges TLR4 and TICAM1 and functionally transmits LPS-TRL4 signal to TICAM1; signaling is proposed to occur in early endosomes after endocytosis of TLR4. May also be involved in IL1-triggered NF-kappa-B activation, functioning upstream of IRAK1, IRAK2, TRAF6, and IKBKB; however, reports are controversial. Involved in IL-18 signaling and is proposed to function as a sorting adaptor for MYD88 in IL-18 signaling during adaptive immune response.<ref>PMID:12721283</ref> <ref>PMID:14519765</ref> <ref>PMID:14517278</ref> <ref>PMID:194121844</ref> <ref>PMID:16603631</ref> <ref>PMID:16757566</ref> <ref>PMID:22685567</ref>  Isoform 2: Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes.<ref>PMID:12721283</ref> <ref>PMID:14519765</ref> <ref>PMID:14517278</ref> <ref>PMID:194121844</ref> <ref>PMID:16603631</ref> <ref>PMID:16757566</ref> <ref>PMID:22685567</ref>  

*[[TIR domain-containing adapter protein|TIR domain-containing adapter protein]]

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Enokizono Y]]

[[Category: Funami K]]

[[Category: Horiuchi M]]

[[Category: Inagaki F]]

[[Category: Kumeta H]]

[[Category: Matsumoto M]]

[[Category: Sarmiento J]]

[[Category: Seya T]]

[[Category: Standley DM]]

[[Category: Yamashita K]]