2lsl: Difference between revisions
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==Solution structure of the C-terminal domain of Tetrahymena telomerase protein p65== | ==Solution structure of the C-terminal domain of Tetrahymena telomerase protein p65== | ||
<StructureSection load='2lsl' size='340' side='right' caption='[[2lsl | <StructureSection load='2lsl' size='340' side='right'caption='[[2lsl]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lsl]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lsl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Tetrahymena_thermophila Tetrahymena thermophila]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LSL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LSL FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lsl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lsl OCA], [https://pdbe.org/2lsl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lsl RCSB], [https://www.ebi.ac.uk/pdbsum/2lsl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lsl ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/LARP7_TETTS LARP7_TETTS] RNA-binding protein required for assembly of the holoenzyme telomerase ribonucleoprotein (RNP) complex (PubMed:15131081, PubMed:15696174, PubMed:16507983, PubMed:17322903, PubMed:20713447, PubMed:22315458, PubMed:22705372). Telomerase is an essential ribonucleoprotein enzyme that copies new telomeric repeats onto chromosome ends by repetitively synthesizing the short telomere-repeat sequence 5'-TTGGGG-3' using an RNA template component TER (PubMed:15696174, PubMed:17322903, PubMed:20713447). TAP65/p65 specifically binds telomerase RNA template TER and is required for biogenesis and placement of the TER stem-terminus element: TAP65/p65 first protects the 3'-end of TER from degradation and acts as a chaperone to correctly fold TER for protein binding; it then bends TER stem-loop IV to position it for interaction of stem-loop IV with catalytic TERT RNA-binding domain (PubMed:15696174, PubMed:17322903, PubMed:20713447, PubMed:22315458, PubMed:22705372).<ref>PMID:15131081</ref> <ref>PMID:15696174</ref> <ref>PMID:16507983</ref> <ref>PMID:17322903</ref> <ref>PMID:20713447</ref> <ref>PMID:22315458</ref> <ref>PMID:22705372</ref> | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 2lsl" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 2lsl" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Telomerase-associated protein|Telomerase-associated protein]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: Cascio | [[Category: Tetrahymena thermophila]] | ||
[[Category: Collins | [[Category: Cascio D]] | ||
[[Category: Feigon | [[Category: Collins K]] | ||
[[Category: Koo | [[Category: Feigon J]] | ||
[[Category: Patel | [[Category: Koo B]] | ||
[[Category: Singh | [[Category: Patel A]] | ||
[[Category: Wang | [[Category: Singh M]] | ||
[[Category: Wang Z]] | |||