2lqh: Difference between revisions
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==NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)== | ==NMR structure of FOXO3a transactivation domains (CR2C-CR3) in complex with CBP KIX domain (2b3l conformation)== | ||
<StructureSection load='2lqh' size='340' side='right' caption='[[2lqh | <StructureSection load='2lqh' size='340' side='right'caption='[[2lqh]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lqh]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lqh]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens] and [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LQH OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LQH FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lqh FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lqh OCA], [https://pdbe.org/2lqh PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lqh RCSB], [https://www.ebi.ac.uk/pdbsum/2lqh PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lqh ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/CBP_MOUSE CBP_MOUSE] Acetylates histones, giving a specific tag for transcriptional activation. Also acetylates non-histone proteins, like NCOA3 and FOXO1. Binds specifically to phosphorylated CREB and enhances its transcriptional activity toward cAMP-responsive genes. Acts as a coactivator of ALX1 in the presence of EP300 (By similarity).<ref>PMID:10207073</ref> <ref>PMID:11701890</ref> <ref>PMID:15220471</ref> <ref>PMID:16287980</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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==See Also== | ==See Also== | ||
*[[CREB-binding protein|CREB-binding protein]] | *[[CREB-binding protein 3D structures|CREB-binding protein 3D structures]] | ||
*[[ | *[[FOX 3D structures|FOX 3D structures]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Mus musculus]] | ||
[[Category: Gasmi-Seabrook | [[Category: Gasmi-Seabrook GMC]] | ||
[[Category: Ikura | [[Category: Ikura M]] | ||
[[Category: Li | [[Category: Li GB]] | ||
[[Category: Mak | [[Category: Mak TW]] | ||
[[Category: Marshall | [[Category: Marshall CB]] | ||
[[Category: Okada | [[Category: Okada H]] | ||
[[Category: Wang | [[Category: Wang F]] | ||
[[Category: Yamamoto | [[Category: Yamamoto K]] | ||