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==Refined Solution NMR Structure of the 50S ribosomal protein L35Ae from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target (NESG) PfR48== | ==Refined Solution NMR Structure of the 50S ribosomal protein L35Ae from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target (NESG) PfR48== | ||
<StructureSection load='2lp6' size='340' side='right'caption='[[2lp6 | <StructureSection load='2lp6' size='340' side='right'caption='[[2lp6]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[2lp6]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Pyrococcus_furiosus_DSM_3638 Pyrococcus furiosus DSM 3638]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LP6 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LP6 FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lp6 OCA], [https://pdbe.org/2lp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lp6 ProSAT]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lp6 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lp6 OCA], [https://pdbe.org/2lp6 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lp6 RCSB], [https://www.ebi.ac.uk/pdbsum/2lp6 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lp6 ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Function == | |||
[https://www.uniprot.org/uniprot/RL35A_PYRFU RL35A_PYRFU] | |||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</StructureSection> | </StructureSection> | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: | [[Category: Pyrococcus furiosus DSM 3638]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Aramini | [[Category: Aramini JM]] | ||
[[Category: Cort | [[Category: Cort JR]] | ||
[[Category: Huang | [[Category: Huang YJ]] | ||
[[Category: Kennedy | [[Category: Kennedy MA]] | ||
[[Category: Liu | [[Category: Liu J]] | ||
[[Category: Ma | [[Category: Ma L]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Rost B]] | |||
[[Category: Rost | [[Category: Shastry R]] | ||
[[Category: Shastry | [[Category: Snyder DA]] | ||
[[Category: Snyder | [[Category: Xiao R]] | ||
[[Category: Xiao | [[Category: Yu B]] | ||
[[Category: Yu | |||
Latest revision as of 08:48, 15 May 2024
Refined Solution NMR Structure of the 50S ribosomal protein L35Ae from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target (NESG) PfR48Refined Solution NMR Structure of the 50S ribosomal protein L35Ae from Pyrococcus furiosus, Northeast Structural Genomics Consortium Target (NESG) PfR48
Structural highlights
FunctionPublication Abstract from PubMedThe ribosome consists of small and large subunits each comprised of dozens of proteins and RNA molecules. However, the functions of many of the individual protomers within the ribosome are still unknown. Here we describe the solution NMR structure of the ribosomal protein RP-L35Ae from the archaeon Pyrococcus furiosus. RP-L35Ae is buried within the large subunit of the ribosome and belongs to Pfam protein domain family PF01247, which is highly conserved in eukaryotes, present in a few archaeal genomes, but absent in bacteria. The protein adopts a six-stranded anti-parallel beta-barrel analogous to the 'tRNA binding motif' fold. The structure of the P. furiosus RP-L35Ae presented here constitutes the first structural representative from this protein domain family. Proteins 2012. (c) 2012 Wiley Periodicals, Inc. Solution NMR structure of the ribosomal protein RP-L35Ae from Pyrococcus furiosus.,Snyder DA, Aramini JM, Yu B, Huang YJ, Xiao R, Cort JR, Shastry R, Ma LC, Liu J, Rost B, Acton TB, Kennedy MA, Montelione GT Proteins. 2012 Mar 16. doi: 10.1002/prot.24071. PMID:22422653[1] From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine. References
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