2lo2: Difference between revisions
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==Solution structure of Sgf11(63-99) zinc finger domain== | ==Solution structure of Sgf11(63-99) zinc finger domain== | ||
<StructureSection load='2lo2' size='340' side='right' caption='[[2lo2 | <StructureSection load='2lo2' size='340' side='right'caption='[[2lo2]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2lo2]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2lo2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae_S288C Saccharomyces cerevisiae S288C]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LO2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LO2 FirstGlance]. <br> | ||
</ | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |||
<tr><td class="sblockLbl"><b>[[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lo2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lo2 OCA], [https://pdbe.org/2lo2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lo2 RCSB], [https://www.ebi.ac.uk/pdbsum/2lo2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lo2 ProSAT]</span></td></tr> | ||
</table> | |||
<tr><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | == Function == | ||
<table> | [https://www.uniprot.org/uniprot/SGF11_YEAST SGF11_YEAST] Component of the transcription regulatory histone acetylation (HAT) complex SAGA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation of approximately 10% of yeast genes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction (SPT3, SPT8 and SPT20) and promoter selectivity, interaction with transcription activators (GCN5, ADA2, ADA3 and TRA1), and chromatin modification through histone acetylation (GCN5) and deubiquitination (UBP8). SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). SGF11 is involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex with SUS1, SGF73 and UBP8 required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. It is required to recruit UBP8 and SUS1 into the SAGA complex.<ref>PMID:15657441</ref> <ref>PMID:15657442</ref> | ||
==See Also== | |||
*[[SAGA-associated factor|SAGA-associated factor]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Saccharomyces cerevisiae]] | [[Category: Large Structures]] | ||
[[Category: Bonnet | [[Category: Saccharomyces cerevisiae S288C]] | ||
[[Category: Devys | [[Category: Bonnet J]] | ||
[[Category: Gao | [[Category: Devys D]] | ||
[[Category: Kieffer | [[Category: Gao X]] | ||
[[Category: Koehler | [[Category: Kieffer B]] | ||
[[Category: Koehler C]] | |||