2lcw: Difference between revisions

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-'''Unreleased structure'''
-The entry 2lcw is ON HOLD  until Paper Publication
+==solution structure of FUS/TLS RRM domain==
+<StructureSection load='2lcw' size='340' side='right'caption='[[2lcw]]' scene=''>
-Authors: Liu, X., Ren, J., Niu, C., Gong, W., Feng, W.
+== Structural highlights ==
+<table><tr><td colspan='2'>[[2lcw]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2LCW OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2LCW FirstGlance]. <br>
-Description: solution structure of FUS/TLS RRM domain
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2lcw FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2lcw OCA], [https://pdbe.org/2lcw PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2lcw RCSB], [https://www.ebi.ac.uk/pdbsum/2lcw PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2lcw ProSAT]</span></td></tr>
+</table>
+== Disease ==
+[https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Frontotemporal dementia with motor neuron disease;Hereditary essential tremor;Amyotrophic lateral sclerosis;Juvenile amyotrophic lateral sclerosis;Myxofibrosarcoma;Myxoid/round cell liposarcoma. A chromosomal aberration involving FUS is found in a patient with malignant myxoid liposarcoma. Translocation t(12;16)(q13;p11) with DDIT3.  A chromosomal aberration involving FUS is a cause of acute myeloid leukemia (AML). Translocation t(16;21)(p11;q22) with ERG.  The disease may be caused by mutations affecting the gene represented in this entry. A chromosomal aberration involving FUS is found in a patient with angiomatoid fibrous histiocytoma. Translocation t(12;16)(q13;p11.2) with ATF1 generates a chimeric FUS/ATF1 protein.  The disease is caused by mutations affecting the gene represented in this entry.  The disease is caused by mutations affecting the gene represented in this entry.
+== Function ==
+[https://www.uniprot.org/uniprot/FUS_HUMAN FUS_HUMAN] Binds both single-stranded and double-stranded DNA and promotes ATP-independent annealing of complementary single-stranded DNAs and D-loop formation in superhelical double-stranded DNA. May play a role in maintenance of genomic integrity.
+__TOC__
+</StructureSection>
+[[Category: Homo sapiens]]
+[[Category: Large Structures]]
+[[Category: Feng W]]
+[[Category: Gong W]]
+[[Category: Liu X]]
+[[Category: Niu C]]
+[[Category: Ren J]]