2l6u: Difference between revisions
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==Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A== | ==Solution NMR Structure of Med25(391-543) Comprising the Activator-Interacting Domain (ACID) of Human Mediator Subuniti 25. Northeast Structural Genomics Consortium Target HR6188A== | ||
<StructureSection load='2l6u' size='340' side='right'caption='[[2l6u | <StructureSection load='2l6u' size='340' side='right'caption='[[2l6u]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[2l6u]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[2l6u]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2L6U OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2L6U FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2l6u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2l6u OCA], [https://pdbe.org/2l6u PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2l6u RCSB], [https://www.ebi.ac.uk/pdbsum/2l6u PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2l6u ProSAT]</span></td></tr> | ||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Charcot-Marie-Tooth disease type 2B2. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:19290556</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/MED25_HUMAN MED25_HUMAN] Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Required for RARA/RXRA-mediated transcription.<ref>PMID:14657022</ref> <ref>PMID:14983011</ref> <ref>PMID:17641689</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Acton | [[Category: Acton TB]] | ||
[[Category: Ciccosanti | [[Category: Ciccosanti C]] | ||
[[Category: Eletsky | [[Category: Eletsky A]] | ||
[[Category: Everett | [[Category: Everett JK]] | ||
[[Category: Janjua | [[Category: Janjua H]] | ||
[[Category: Montelione | [[Category: Montelione GT]] | ||
[[Category: Ryuechan WT]] | |||
[[Category: Ryuechan | [[Category: Shastry R]] | ||
[[Category: Shastry | [[Category: Sukumaran DK]] | ||
[[Category: Sukumaran | [[Category: Szyperski T]] | ||
[[Category: Szyperski | [[Category: Xiao R]] | ||
[[Category: Xiao | |||