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==NMR structure of the PASTA domain 3 and 4 of Mycobacterium tuberculosis of PknB==
==NMR structure of the PASTA domain 3 and 4 of Mycobacterium tuberculosis of PknB==
<StructureSection load='2kuf' size='340' side='right'caption='[[2kuf]], [[NMR_Ensembles_of_Models | 30 NMR models]]' scene=''>
<StructureSection load='2kuf' size='340' side='right'caption='[[2kuf]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[2kuf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Myctu Myctu]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUF FirstGlance]. <br>
<table><tr><td colspan='2'>[[2kuf]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mycobacterium_tuberculosis_H37Rv Mycobacterium tuberculosis H37Rv]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2KUF OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2KUF FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat"><div style='overflow: auto; max-height: 3em;'>[[2kud|2kud]], [[2kue|2kue]], [[2kui|2kui]]</div></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">Rv0014c ([https://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=83332 MYCTU])</td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[https://en.wikipedia.org/wiki/Non-specific_serine/threonine_protein_kinase Non-specific serine/threonine protein kinase], with EC number [https://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.11.1 2.7.11.1] </span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuf OCA], [https://pdbe.org/2kuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kuf RCSB], [https://www.ebi.ac.uk/pdbsum/2kuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kuf ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2kuf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2kuf OCA], [https://pdbe.org/2kuf PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2kuf RCSB], [https://www.ebi.ac.uk/pdbsum/2kuf PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2kuf ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU]] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>
[https://www.uniprot.org/uniprot/PKNB_MYCTU PKNB_MYCTU] Key component of a signal transduction pathway that regulates cell growth and cell division via phosphorylation of target proteins such as GarA, GlmU, PapA5, PbpA, FhaB (Rv0019c), FhaA (Rv0020c), MviN, PstP, EmbR, Rv1422, Rv1747 and RseA. Shows a strong preference for Thr versus Ser as the phosphoacceptor.<ref>PMID:15985609</ref> <ref>PMID:15978616</ref> <ref>PMID:15987910</ref> <ref>PMID:16817899</ref> <ref>PMID:16980473</ref> <ref>PMID:16436437</ref> <ref>PMID:19826007</ref> <ref>PMID:19121323</ref> <ref>PMID:20025669</ref> <ref>PMID:21423706</ref> <ref>PMID:22275220</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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</StructureSection>
</StructureSection>
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Myctu]]
[[Category: Mycobacterium tuberculosis H37Rv]]
[[Category: Non-specific serine/threonine protein kinase]]
[[Category: Barthe P]]
[[Category: Barthe, P]]
[[Category: Cohen-Gonsaud M]]
[[Category: Cohen-Gonsaud, M]]
[[Category: Mukamolova G]]
[[Category: Mukamolova, G]]
[[Category: Roumestand C]]
[[Category: Roumestand, C]]
[[Category: External domain]]
[[Category: Kinase]]
[[Category: Resuscitation]]
[[Category: Serine/threonine-protein kinase]]
[[Category: Signaling]]
[[Category: Stpk]]
[[Category: Transferase]]

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