2bru: Difference between revisions

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New page: left|200px<br /><applet load="2bru" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bru" /> '''COMPLEX OF THE DOMAIN I AND DOMAIN III OF ES...
 
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[[Image:2bru.gif|left|200px]]<br /><applet load="2bru" size="450" color="white" frame="true" align="right" spinBox="true"
caption="2bru" />
'''COMPLEX OF THE DOMAIN I AND DOMAIN III OF ESCHERICHIA COLI TRANSHYDROGENASE'''<br />


==About this Structure==
==Complex of the domain I and domain III of Escherichia coli transhydrogenase==
2BRU is a [http://en.wikipedia.org/wiki/Protein_complex Protein complex] structure of sequences from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli] with NAD and NAP as [http://en.wikipedia.org/wiki/ligands ligands]. Active as [http://en.wikipedia.org/wiki/NAD(P)(+)_transhydrogenase_(AB-specific) NAD(P)(+) transhydrogenase (AB-specific)], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.6.1.2 1.6.1.2] Full crystallographic information is available from [http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BRU OCA].  
<StructureSection load='2bru' size='340' side='right'caption='[[2bru]]' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[2bru]] is a 3 chain structure with sequence from [https://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2BRU OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=2BRU FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=NAD:NICOTINAMIDE-ADENINE-DINUCLEOTIDE'>NAD</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=2bru FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2bru OCA], [https://pdbe.org/2bru PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=2bru RCSB], [https://www.ebi.ac.uk/pdbsum/2bru PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=2bru ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/PNTA_ECOLI PNTA_ECOLI] The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/br/2bru_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2bru ConSurf].
<div style="clear:both"></div>
 
==See Also==
*[[NAD(P) transhydrogenase 3D structures|NAD(P) transhydrogenase 3D structures]]
__TOC__
</StructureSection>
[[Category: Escherichia coli]]
[[Category: Escherichia coli]]
[[Category: NAD(P)(+) transhydrogenase (AB-specific)]]
[[Category: Large Structures]]
[[Category: Protein complex]]
[[Category: Johansson T]]
[[Category: Johansson, T.]]
[[Category: Karlsson BG]]
[[Category: Karlsson, B.G.]]
[[Category: Leckner J]]
[[Category: Leckner, J.]]
[[Category: Pedersen A]]
[[Category: Pedersen, A.]]
[[Category: NAD]]
[[Category: NAP]]
[[Category: inner membrane]]
[[Category: membrane]]
[[Category: nad]]
[[Category: nadp]]
[[Category: oxidoreductase]]
[[Category: paramagnetic nmr]]
[[Category: transhydrogenase]]
[[Category: transmembrane]]
 
''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Wed Nov 21 08:53:27 2007''

Latest revision as of 08:33, 15 May 2024

Complex of the domain I and domain III of Escherichia coli transhydrogenaseComplex of the domain I and domain III of Escherichia coli transhydrogenase

Structural highlights

2bru is a 3 chain structure with sequence from Escherichia coli. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Ligands:,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

PNTA_ECOLI The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane.

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

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