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==SOLUTION STRUCTURE OF THE SECOND PDZ DOMAIN OF POSTSYNAPTIC DENSITY-95==
 
<StructureSection load='1qlc' size='340' side='right' caption='[[1qlc]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''>
==Solution structure of the second PDZ domain of Postsynaptic Density-95==
<StructureSection load='1qlc' size='340' side='right'caption='[[1qlc]]' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[1qlc]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Buffalo_rat Buffalo rat]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QLC OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1QLC FirstGlance]. <br>
<table><tr><td colspan='2'>[[1qlc]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Rattus_norvegicus Rattus norvegicus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1QLC OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1QLC FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1be9|1be9]], [[1bfe|1bfe]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1qlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qlc OCA], [http://pdbe.org/1qlc PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=1qlc RCSB], [http://www.ebi.ac.uk/pdbsum/1qlc PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1qlc FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1qlc OCA], [https://pdbe.org/1qlc PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1qlc RCSB], [https://www.ebi.ac.uk/pdbsum/1qlc PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1qlc ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT]] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>
[https://www.uniprot.org/uniprot/DLG4_RAT DLG4_RAT] Interacts with the cytoplasmic tail of NMDA receptor subunits and shaker-type potassium channels. Required for synaptic plasticity associated with NMDA receptor signaling. Overexpression or depletion of DLG4 changes the ratio of excitatory to inhibitory synapses in hippocampal neurons. May reduce the amplitude of ASIC3 acid-evoked currents by retaining the channel intracellularly. May regulate the intracellular trafficking of ADR1B.<ref>PMID:15317815</ref> <ref>PMID:15358863</ref>  
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
Check<jmol>
   <jmolCheckbox>
   <jmolCheckbox>
     <scriptWhenChecked>select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ql/1qlc_consurf.spt"</scriptWhenChecked>
     <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/ql/1qlc_consurf.spt"</scriptWhenChecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
     <text>to colour the structure by Evolutionary Conservation</text>
     <text>to colour the structure by Evolutionary Conservation</text>
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</div>
</div>
<div class="pdbe-citations 1qlc" style="background-color:#fffaf0;"></div>
<div class="pdbe-citations 1qlc" style="background-color:#fffaf0;"></div>
==See Also==
*[[Postsynaptic density protein 3D structures|Postsynaptic density protein 3D structures]]
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Buffalo rat]]
[[Category: Large Structures]]
[[Category: Hung, F]]
[[Category: Rattus norvegicus]]
[[Category: Li, M]]
[[Category: Hung F]]
[[Category: Tochio, H]]
[[Category: Li M]]
[[Category: Zhang, M]]
[[Category: Tochio H]]
[[Category: Neuronal nitric oxide synthase]]
[[Category: Zhang M]]
[[Category: Nmda receptor binding]]
[[Category: Pdz domain]]
[[Category: Peptide recognition]]

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