8fyt: Difference between revisions

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'''Unreleased structure'''


The entry 8fyt is ON HOLD
==LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex==
 
<StructureSection load='8fyt' size='340' side='right'caption='[[8fyt]], [[Resolution|resolution]] 2.64&Aring;' scene=''>
Authors:  
== Structural highlights ==
 
<table><tr><td colspan='2'>[[8fyt]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8FYT OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8FYT FirstGlance]. <br>
Description:  
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 2.64&#8491;</td></tr>
[[Category: Unreleased Structures]]
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=7LD:(8ALPHA)-N,N-DIETHYL-6-METHYL-9,10-DIDEHYDROERGOLINE-8-CARBOXAMIDE'>7LD</scene>, <scene name='pdbligand=J40:[(2R)-1-[oxidanyl-[(2R,3R,5S,6R)-2,3,5,6-tetrakis(oxidanyl)-4-phosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-3-tetradecanoyloxy-propan-2-yl]+(5E,8E)-hexadeca-5,8,11,14-tetraenoate'>J40</scene>, <scene name='pdbligand=Y01:CHOLESTEROL+HEMISUCCINATE'>Y01</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8fyt FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8fyt OCA], [https://pdbe.org/8fyt PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8fyt RCSB], [https://www.ebi.ac.uk/pdbsum/8fyt PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8fyt ProSAT]</span></td></tr>
</table>
== Disease ==
[https://www.uniprot.org/uniprot/5HT1A_HUMAN 5HT1A_HUMAN] Menstrual cycle-dependent periodic fever. The disease is caused by variants affecting the gene represented in this entry.
== Function ==
[https://www.uniprot.org/uniprot/5HT1A_HUMAN 5HT1A_HUMAN] G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.<ref>PMID:22957663</ref> <ref>PMID:3138543</ref> <ref>PMID:8138923</ref> <ref>PMID:8393041</ref>
== References ==
<references/>
__TOC__
</StructureSection>
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Capper MJ]]
[[Category: Wacker D]]
[[Category: Warren AL]]
[[Category: Zilberg G]]

Latest revision as of 08:17, 15 May 2024

LSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complexLSD-bound serotonin 1A (5-HT1A) receptor-Gi1 protein complex

Structural highlights

8fyt is a 4 chain structure with sequence from Homo sapiens. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Electron Microscopy, Resolution 2.64Å
Ligands:, ,
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Disease

5HT1A_HUMAN Menstrual cycle-dependent periodic fever. The disease is caused by variants affecting the gene represented in this entry.

Function

5HT1A_HUMAN G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling inhibits adenylate cyclase activity and activates a phosphatidylinositol-calcium second messenger system that regulates the release of Ca(2+) ions from intracellular stores. Plays a role in the regulation of 5-hydroxytryptamine release and in the regulation of dopamine and 5-hydroxytryptamine metabolism. Plays a role in the regulation of dopamine and 5-hydroxytryptamine levels in the brain, and thereby affects neural activity, mood and behavior. Plays a role in the response to anxiogenic stimuli.[1] [2] [3] [4]

References

  1. ↑ Singh P, Paila YD, Chattopadhyay A. Role of glycosphingolipids in the function of human serotonin₁A receptors. J Neurochem. 2012 Dec;123(5):716-24. PMID:22957663 doi:10.1111/jnc.12008
  2. ↑ Fargin A, Raymond JR, Lohse MJ, Kobilka BK, Caron MG, Lefkowitz RJ. The genomic clone G-21 which resembles a beta-adrenergic receptor sequence encodes the 5-HT1A receptor. Nature. 1988 Sep 22;335(6188):358-60. PMID:3138543 doi:10.1038/335358a0
  3. ↑ Harrington MA, Shaw K, Zhong P, Ciaranello RD. Agonist-induced desensitization and loss of high-affinity binding sites of stably expressed human 5-HT1A receptors. J Pharmacol Exp Ther. 1994 Mar;268(3):1098-106 PMID:8138923
  4. ↑ Aune TM, McGrath KM, Sarr T, Bombara MP, Kelley KA. Expression of 5HT1a receptors on activated human T cells. Regulation of cyclic AMP levels and T cell proliferation by 5-hydroxytryptamine. J Immunol. 1993 Aug 1;151(3):1175-83 PMID:8393041

8fyt, resolution 2.64Å

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