1x9a: Difference between revisions

← Older edit

Proteopedia Page Contributors and Editors (what is this?)Proteopedia Page Contributors and Editors (what is this?)

OCA

@@ Line 1: / Line 1: @@
-[[Image:1x9a.png|left|200px]]
-{{STRUCTURE_1x9a|  PDB=1x9a  |  SCENE=  }}
+==Solution NMR Structure of Protein Tm0979 from Thermotoga maritima. Ontario Center for Structural Proteomics Target TM0979_1_87; Northeast Structural Genomics Consortium Target VT98.==
+<StructureSection load='1x9a' size='340' side='right'caption='[[1x9a]]' scene=''>
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1x9a]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9A OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X9A FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x9a FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x9a OCA], [https://pdbe.org/1x9a PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x9a RCSB], [https://www.ebi.ac.uk/pdbsum/1x9a PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x9a ProSAT], [https://www.topsan.org/Proteins/NESGC/1x9a TOPSAN]</span></td></tr>
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/Q9X074_THEMA Q9X074_THEMA]
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/x9/1x9a_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1x9a ConSurf].
+<div style="clear:both"></div>
+<div style="background-color:#fffaf0;">
+== Publication Abstract from PubMed ==
+We report herein the NMR structure of Tm0979, a structural proteomics target from Thermotoga maritima. The Tm0979 fold consists of four beta/alpha units, which form a central parallel beta-sheet with strand order 1234. The first three helices pack toward one face of the sheet and the fourth helix packs against the other face. The protein forms a dimer by adjacent parallel packing of the fourth helices sandwiched between the two beta-sheets. This fold is very interesting from several points of view. First, it represents the first structure determination for the DsrH family of conserved hypothetical proteins, which are involved in oxidation of intracellular sulfur but have no defined molecular function. Based on structure and sequence analysis, possible functions are discussed. Second, the fold of Tm0979 most closely resembles YchN-like folds; however the proteins that adopt these folds differ in secondary structural elements and quaternary structure. Comparison of these proteins provides insight into possible mechanisms of evolution of quaternary structure through a simple mechanism of hydrophobicity-changing mutations of one or two residues. Third, the Tm0979 fold is found to be similar to flavodoxin-like folds and beta/alpha barrel proteins, and may provide a link between these very abundant folds and putative ancestral half-barrel proteins.
-===Solution NMR Structure of Protein Tm0979 from Thermotoga maritima. Ontario Center for Structural Proteomics Target TM0979_1_87; Northeast Structural Genomics Consortium Target VT98.===
+A novel member of the YchN-like fold: solution structure of the hypothetical protein Tm0979 from Thermotoga maritima.,Gaspar JA, Liu C, Vassall KA, Meglei G, Stephen R, Stathopulos PB, Pineda-Lucena A, Wu B, Yee A, Arrowsmith CH, Meiering EM Protein Sci. 2005 Jan;14(1):216-23. PMID:15608123<ref>PMID:15608123</ref>
-{{ABSTRACT_PUBMED_15608123}}
+From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
+</div>
-==About this Structure==
+<div class="pdbe-citations 1x9a" style="background-color:#fffaf0;"></div>
-[[1x9a]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Thermotoga_maritima Thermotoga maritima]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X9A OCA].
+== References ==
+<references/>
-==Reference==
+__TOC__
-<ref group="xtra">PMID:015608123</ref><references group="xtra"/>
+</StructureSection>
+[[Category: Large Structures]]
 [[Category: Thermotoga maritima]]
-[[Category: Arrowsmith, C H.]]
+[[Category: Arrowsmith CH]]
-[[Category: Gaspar, J A.]]
+[[Category: Gaspar JA]]
-[[Category: Liu, C.]]
+[[Category: Liu C]]
-[[Category: Meglei, G.]]
+[[Category: Meglei G]]
-[[Category: Meiering, E M.]]
+[[Category: Meiering EM]]
-[[Category: NESG, Northeast Structural Genomics Consortium.]]
+[[Category: Pineda-Lucena A]]
-[[Category: Pineda-Lucena, A.]]
+[[Category: Stathopulos PB]]
-[[Category: Stathopulos, P B.]]
+[[Category: Stephen R]]
-[[Category: Stephen, R.]]
+[[Category: Vassall KA]]
-[[Category: Vassall, K A.]]
+[[Category: Wu B]]
-[[Category: Wu, B.]]
+[[Category: Yee A]]
-[[Category: Yee, A.]]
-[[Category: Beta-alpha protein]]
-[[Category: Dimer]]
-[[Category: Hypothetical protein]]
-[[Category: Nesg]]
-[[Category: Northeast structural genomics consortium]]
-[[Category: Ocsp]]
-[[Category: Protein structure initiative]]
-[[Category: Psi]]
-[[Category: Structural genomic]]
-[[Category: Unknown function]]