1x6d: Difference between revisions
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==Solution structures of the PDZ domain of human Interleukin-16== | ==Solution structures of the PDZ domain of human Interleukin-16== | ||
<StructureSection load='1x6d' size='340' side='right'caption='[[1x6d | <StructureSection load='1x6d' size='340' side='right'caption='[[1x6d]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/ | <table><tr><td colspan='2'>[[1x6d]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X6D OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X6D FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6d OCA], [https://pdbe.org/1x6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6d RCSB], [https://www.ebi.ac.uk/pdbsum/1x6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6d TOPSAN]</span></td></tr> | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x6d FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x6d OCA], [https://pdbe.org/1x6d PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x6d RCSB], [https://www.ebi.ac.uk/pdbsum/1x6d PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x6d ProSAT], [https://www.topsan.org/Proteins/RSGI/1x6d TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[https://www.uniprot.org/uniprot/IL16_HUMAN IL16_HUMAN] Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 1 may act as a scaffolding protein that anchors ion channels in the membrane.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> Isoform 3 is involved in cell cycle progression in T-cells. Appears to be involved in transcriptional regulation of SKP2 and is probably part of a transcriptional repression complex on the core promoter of the SKP2 gene. May act as a scaffold for GABPB1 (the DNA-binding subunit the GABP transcription factor complex) and HDAC3 thus maintaining transcriptional repression and blocking cell cycle progression in resting T-cells.<ref>PMID:14734747</ref> <ref>PMID:18097041</ref> | |||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Inoue | [[Category: Inoue M]] | ||
[[Category: Kigawa | [[Category: Kigawa T]] | ||
[[Category: Koshiba | [[Category: Koshiba S]] | ||
[[Category: Sato M]] | |||
[[Category: Sato | [[Category: Yokoyama S]] | ||
[[Category: Yokoyama | |||