1x5b: Difference between revisions
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==The solution structure of the VHS domain of human Signal transducing adaptor molecule 2== | ==The solution structure of the VHS domain of human Signal transducing adaptor molecule 2== | ||
<StructureSection load='1x5b' size='340' side='right' caption='[[1x5b | <StructureSection load='1x5b' size='340' side='right'caption='[[1x5b]]' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[1x5b]] is a 1 chain structure with sequence from [ | <table><tr><td colspan='2'>[[1x5b]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1X5B OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1X5B FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1x5b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1x5b OCA], [https://pdbe.org/1x5b PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1x5b RCSB], [https://www.ebi.ac.uk/pdbsum/1x5b PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1x5b ProSAT], [https://www.topsan.org/Proteins/RSGI/1x5b TOPSAN]</span></td></tr> | ||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/STAM2_HUMAN STAM2_HUMAN] Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: | [[Category: Large Structures]] | ||
[[Category: | [[Category: Inoue M]] | ||
[[Category: | [[Category: Kigawa T]] | ||
[[Category: | [[Category: Koshiba S]] | ||
[[Category: Tochio | [[Category: Tochio N]] | ||
[[Category: Yokoyama | [[Category: Yokoyama S]] | ||
Latest revision as of 17:00, 9 May 2024
The solution structure of the VHS domain of human Signal transducing adaptor molecule 2The solution structure of the VHS domain of human Signal transducing adaptor molecule 2
Structural highlights
FunctionSTAM2_HUMAN Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity). Evolutionary Conservation Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf. |
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