1wxl: Difference between revisions

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-[[Image:1wxl.gif|left|200px]]
- {{Structure
+==Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT==
-|PDB= 1wxl |SIZE=350|CAPTION= <scene name='initialview01'>1wxl</scene>
+<StructureSection load='1wxl' size='340' side='right'caption='[[1wxl]]' scene=''>
-|SITE=
+== Structural highlights ==
-|LIGAND=
+<table><tr><td colspan='2'>[[1wxl]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WXL FirstGlance]. <br>
-|ACTIVITY=
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-|GENE=
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wxl FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wxl OCA], [https://pdbe.org/1wxl PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wxl RCSB], [https://www.ebi.ac.uk/pdbsum/1wxl PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wxl ProSAT]</span></td></tr>
-}}
+</table>
+== Function ==
-'''Solution Structure of the HMG-box domain in the SSRP1 subunit of FACT'''
+[https://www.uniprot.org/uniprot/SSRP1_DROME SSRP1_DROME] Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes.<ref>PMID:12815073</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
-==About this Structure==
+Check<jmol>
-WXL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Drosophila_melanogaster Drosophila melanogaster]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WXL OCA].
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wx/1wxl_consurf.spt"</scriptWhenChecked>
-==Reference==
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
-Solution structure of the HMG-box domain in the SSRP1 subunit of FACT., Kasai N, Tsunaka Y, Ohki I, Hirose S, Morikawa K, Tate S, J Biomol NMR. 2005 May;32(1):83-8. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16041486 16041486]
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wxl ConSurf].
+<div style="clear:both"></div>
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Drosophila melanogaster]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Hirose, S.]]
+[[Category: Hirose S]]
-[[Category: Kasai, N.]]
+[[Category: Kasai N]]
-[[Category: Morikawa, K.]]
+[[Category: Morikawa K]]
-[[Category: Ohki, I.]]
+[[Category: Ohki I]]
-[[Category: Tate, S.]]
+[[Category: Tate S]]
-[[Category: Tsunaka, Y.]]
+[[Category: Tsunaka Y]]
-[[Category: fact]]
-[[Category: hmg]]
-[[Category: ssrp1]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Mar 20 15:02:47 2008''