1wr7: Difference between revisions

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[[Image:1wr7.png|left|200px]]


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==Solution structure of the third WW domain of Nedd4-2==
The line below this paragraph, containing "STRUCTURE_1wr7", creates the "Structure Box" on the page.
<StructureSection load='1wr7' size='340' side='right'caption='[[1wr7]]' scene=''>
You may change the PDB parameter (which sets the PDB file loaded into the applet)
== Structural highlights ==
or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
<table><tr><td colspan='2'>[[1wr7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WR7 FirstGlance]. <br>
or leave the SCENE parameter empty for the default display.
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wr7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wr7 OCA], [https://pdbe.org/1wr7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wr7 RCSB], [https://www.ebi.ac.uk/pdbsum/1wr7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wr7 ProSAT]</span></td></tr>
{{STRUCTURE_1wr7| PDB=1wr7 |  SCENE= }}
</table>
== Function ==
[https://www.uniprot.org/uniprot/NED4L_MOUSE NED4L_MOUSE] E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.<ref>PMID:11149908</ref> <ref>PMID:12424229</ref> <ref>PMID:11742982</ref> <ref>PMID:11244092</ref> <ref>PMID:15123669</ref>
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
Check<jmol>
  <jmolCheckbox>
    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wr/1wr7_consurf.spt"</scriptWhenChecked>
    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
    <text>to colour the structure by Evolutionary Conservation</text>
  </jmolCheckbox>
</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wr7 ConSurf].
<div style="clear:both"></div>


===Solution structure of the third WW domain of Nedd4-2===
==See Also==
 
*[[Ubiquitin protein ligase 3D structures|Ubiquitin protein ligase 3D structures]]
 
== References ==
==About this Structure==
<references/>
1WR7 is a 1 chain structure of sequence from [http://en.wikipedia.org/wiki/Mus_musculus Mus musculus]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WR7 OCA].
__TOC__
</StructureSection>
[[Category: Large Structures]]
[[Category: Mus musculus]]
[[Category: Mus musculus]]
[[Category: Booker, G W.]]
[[Category: Booker GW]]
[[Category: Kowalski, K.]]
[[Category: Kowalski K]]
[[Category: Merkel, A L.]]
[[Category: Merkel AL]]
[[Category: All-beta]]
 
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Feb 16 17:08:53 2009''

Latest revision as of 16:47, 9 May 2024

Solution structure of the third WW domain of Nedd4-2Solution structure of the third WW domain of Nedd4-2

Structural highlights

1wr7 is a 1 chain structure with sequence from Mus musculus. Full experimental information is available from OCA. For a guided tour on the structure components use FirstGlance.
Method:Solution NMR
Resources:FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

NED4L_MOUSE E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Inhibits TGF-beta signaling by triggering SMAD2 and TGFBR1 ubiquitination and proteasome-dependent degradation. Promotes ubiquitination and internalization of various plasma membrane channels such as ENaC, Nav1.2, Nav1.3, Nav1.5, Nav1.7, Nav1.8, Kv1.3, EAAT1 or CLC5. Promotes ubiquitination and degradation of SGK1 and TNK2.[1] [2] [3] [4] [5]

Evolutionary Conservation

Check, as determined by ConSurfDB. You may read the explanation of the method and the full data available from ConSurf.

See Also

References

  1. ↑ Kamynina E, Debonneville C, Bens M, Vandewalle A, Staub O. A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel. FASEB J. 2001 Jan;15(1):204-214. PMID:11149908 doi:http://dx.doi.org/10.1096/fj.00-0191com
  2. ↑ Fotia AB, Dinudom A, Shearwin KE, Koch JP, Korbmacher C, Cook DI, Kumar S. The role of individual Nedd4-2 (KIAA0439) WW domains in binding and regulating epithelial sodium channels. FASEB J. 2003 Jan;17(1):70-2. Epub 2002 Nov 1. PMID:12424229 doi:http://dx.doi.org/10.1096/fj.02-0497fje
  3. ↑ Debonneville C, Flores SY, Kamynina E, Plant PJ, Tauxe C, Thomas MA, Munster C, Chraibi A, Pratt JH, Horisberger JD, Pearce D, Loffing J, Staub O. Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression. EMBO J. 2001 Dec 17;20(24):7052-9. PMID:11742982 doi:http://dx.doi.org/10.1093/emboj/20.24.7052
  4. ↑ Harvey KF, Dinudom A, Cook DI, Kumar S. The Nedd4-like protein KIAA0439 is a potential regulator of the epithelial sodium channel. J Biol Chem. 2001 Mar 16;276(11):8597-601. Epub 2001 Jan 17. PMID:11244092 doi:http://dx.doi.org/10.1074/jbc.C000906200
  5. ↑ Fotia AB, Ekberg J, Adams DJ, Cook DI, Poronnik P, Kumar S. Regulation of neuronal voltage-gated sodium channels by the ubiquitin-protein ligases Nedd4 and Nedd4-2. J Biol Chem. 2004 Jul 9;279(28):28930-5. Epub 2004 Apr 27. PMID:15123669 doi:http://dx.doi.org/10.1074/jbc.M402820200
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