1whb: Difference between revisions

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-{{Seed}}
-[[Image:1whb.png|left|200px]]
-<!--
+==Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)==
-The line below this paragraph, containing "STRUCTURE_1whb", creates the "Structure Box" on the page.
+<StructureSection load='1whb' size='340' side='right'caption='[[1whb]]' scene=''>
-You may change the PDB parameter (which sets the PDB file loaded into the applet)
+== Structural highlights ==
-or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
+<table><tr><td colspan='2'>[[1whb]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHB OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WHB FirstGlance]. <br>
-or leave the SCENE parameter empty for the default display.
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
--->
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1whb FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1whb OCA], [https://pdbe.org/1whb PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1whb RCSB], [https://www.ebi.ac.uk/pdbsum/1whb PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1whb ProSAT], [https://www.topsan.org/Proteins/RSGI/1whb TOPSAN]</span></td></tr>
-{{STRUCTURE_1whb|  PDB=1whb  |  SCENE=  }}
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/UBP8_HUMAN UBP8_HUMAN] Hydrolase that can remove conjugated ubiquitin from proteins and therefore plays an important regulatory role at the level of protein turnover by preventing degradation. Converts both 'Lys-48' an 'Lys-63'-linked ubiquitin chains. Catalytic activity is enhanced in the M phase. Involved in cell proliferation. Required to enter into S phase in response to serum stimulation. May regulate T-cell anergy mediated by RNF128 via the formation of a complex containing RNF128 and OTUB1. Probably regulates the stability of STAM2 and RASGRF1. Regulates endosomal ubiquitin dynamics, cargo sorting, membrane traffic at early endosomes, and maintenance of ESCRT-0 stability. The level of protein ubiquitination on endosomes is essential for maintaining the morphology of the organelle. Deubiquitinates EPS15 and controles tyrosine kinase stability. Removes conjugated ubiquitin from EGFR thus regulating EGFR degradation and downstream MAPK signaling. Involved in acrosome biogenesis through interaction with the spermatid ESCRT-0 complex and microtubules. Deubiquitinates BIRC6/bruce and KIF23/MKLP1.<ref>PMID:9628861</ref> <ref>PMID:16520378</ref> <ref>PMID:17711858</ref> <ref>PMID:18329369</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wh/1whb_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1whb ConSurf].
+<div style="clear:both"></div>
-===Solution structure of the Rhodanese-like domain in human ubiquitin specific protease 8 (UBP8)===
+==See Also==
+*[[Thioesterase 3D structures|Thioesterase 3D structures]]
+== References ==
-==About this Structure==
+<references/>
-WHB is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WHB OCA].
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: Single protein]]
+[[Category: Large Structures]]
-[[Category: Ubiquitin thiolesterase]]
+[[Category: Inoue M]]
-[[Category: Inoue, M.]]
+[[Category: Kigawa T]]
-[[Category: Kigawa, T.]]
+[[Category: Koshiba S]]
-[[Category: Koshiba, S.]]
+[[Category: Saito K]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Yokoyama S]]
-[[Category: Saito, K.]]
-[[Category: Yokoyama, S.]]
-[[Category: Deubiqutinating enzyme]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]
-[[Category: Ubpy]]
-''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Sep 28 20:25:40 2008''