1wf2: Difference between revisions

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-[[Image:1wf2.png|left|200px]]
-{{STRUCTURE_1wf2|  PDB=1wf2  |  SCENE=  }}
+==Solution structure of RRM domain in HNRPC protein==
+<StructureSection load='1wf2' size='340' side='right'caption='[[1wf2]]' scene=''>
-===Solution structure of RRM domain in HNRPC protein===
+== Structural highlights ==
+<table><tr><td colspan='2'>[[1wf2]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF2 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=1WF2 FirstGlance]. <br>
+</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Solution NMR</td></tr>
-==About this Structure==
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=1wf2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1wf2 OCA], [https://pdbe.org/1wf2 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=1wf2 RCSB], [https://www.ebi.ac.uk/pdbsum/1wf2 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=1wf2 ProSAT], [https://www.topsan.org/Proteins/RSGI/1wf2 TOPSAN]</span></td></tr>
-[[1wf2]] is a 1 chain structure of [[Nucleoprotein]] with sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1WF2 OCA].
+</table>
+== Function ==
+[https://www.uniprot.org/uniprot/HNRPC_HUMAN HNRPC_HUMAN] Binds pre-mRNA and nucleates the assembly of 40S hnRNP particles. Single HNRNPC tetramers bind 230-240 nucleotides. Trimers of HNRNPC tetramers bind 700 nucleotides. May play a role in the early steps of spliceosome assembly and pre-mRNA splicing. Interacts with poly-U tracts in the 3'-UTR or 5'-UTR of mRNA and modulates the stability and the level of translation of bound mRNA molecules.<ref>PMID:8264621</ref> <ref>PMID:7567451</ref> <ref>PMID:12509468</ref> <ref>PMID:16010978</ref>
+== Evolutionary Conservation ==
+[[Image:Consurf_key_small.gif|200px|right]]
+Check<jmol>
+  <jmolCheckbox>
+    <scriptWhenChecked>; select protein; define ~consurf_to_do selected; consurf_initial_scene = true; script "/wiki/ConSurf/wf/1wf2_consurf.spt"</scriptWhenChecked>
+    <scriptWhenUnchecked>script /wiki/extensions/Proteopedia/spt/initialview01.spt</scriptWhenUnchecked>
+    <text>to colour the structure by Evolutionary Conservation</text>
+  </jmolCheckbox>
+</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=1wf2 ConSurf].
+<div style="clear:both"></div>
 ==See Also==
-*[[Nucleoprotein|Nucleoprotein]]
+*[[Nucleoprotein 3D structures|Nucleoprotein 3D structures]]
+== References ==
+<references/>
+__TOC__
+</StructureSection>
 [[Category: Homo sapiens]]
-[[Category: He, F.]]
+[[Category: Large Structures]]
-[[Category: Inoue, M.]]
+[[Category: He F]]
-[[Category: Kigawa, T.]]
+[[Category: Inoue M]]
-[[Category: Muto, Y.]]
+[[Category: Kigawa T]]
-[[Category: RSGI, RIKEN Structural Genomics/Proteomics Initiative.]]
+[[Category: Muto Y]]
-[[Category: Shirouzu, M.]]
+[[Category: Shirouzu M]]
-[[Category: Terada, T.]]
+[[Category: Terada T]]
-[[Category: Yokoyama, S.]]
+[[Category: Yokoyama S]]
-[[Category: Hnrpc protein]]
-[[Category: Riken structural genomics/proteomics initiative]]
-[[Category: Rna binding protein]]
-[[Category: Rrm domain]]
-[[Category: Rsgi]]
-[[Category: Structural genomic]]