8th7: Difference between revisions
Jump to navigation
Jump to search
New page: '''Unreleased structure''' The entry 8th7 is ON HOLD Authors: Hughes, M.P., Taylor, J.P. Description: Crystal Structure of the G3BP1 NTF2-like domain bound to the Caprin1 peptide [[Cat... |
No edit summary |
||
| (3 intermediate revisions by the same user not shown) | |||
| Line 1: | Line 1: | ||
==Crystal Structure of the G3BP1 NTF2-like domain bound to the Caprin1 peptide== | |||
<StructureSection load='8th7' size='340' side='right'caption='[[8th7]], [[Resolution|resolution]] 2.88Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[8th7]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=8TH7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=8TH7 FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.88Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=8th7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=8th7 OCA], [https://pdbe.org/8th7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=8th7 RCSB], [https://www.ebi.ac.uk/pdbsum/8th7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=8th7 ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/G3BP1_HUMAN G3BP1_HUMAN] May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.<ref>PMID:9889278</ref> <ref>PMID:11604510</ref> | |||
==See Also== | |||
*[[3D structures of G3BP|3D structures of G3BP]] | |||
== References == | |||
[[Category: | <references/> | ||
[[Category: Hughes | __TOC__ | ||
[[Category: Taylor | </StructureSection> | ||
[[Category: Homo sapiens]] | |||
[[Category: Large Structures]] | |||
[[Category: Hughes MP]] | |||
[[Category: Taylor JP]] | |||
Latest revision as of 15:47, 9 May 2024
Crystal Structure of the G3BP1 NTF2-like domain bound to the Caprin1 peptideCrystal Structure of the G3BP1 NTF2-like domain bound to the Caprin1 peptide
Structural highlights
FunctionG3BP1_HUMAN May be a regulated effector of stress granule assembly. Phosphorylation-dependent sequence-specific endoribonuclease in vitro. Cleaves exclusively between cytosine and adenine and cleaves MYC mRNA preferentially at the 3'-UTR. ATP- and magnesium-dependent helicase. Unwinds preferentially partial DNA and RNA duplexes having a 17 bp annealed portion and either a hanging 3' tail or hanging tails at both 5'- and 3'-ends. Unwinds DNA/DNA, RNA/DNA, and RNA/RNA substrates with comparable efficiency. Acts unidirectionally by moving in the 5' to 3' direction along the bound single-stranded DNA.[1] [2] See AlsoReferences
|
| ||||||||||||||||