5hvq: Difference between revisions

<StructureSection load='5hvq' size='340' side='right'caption='[[5hvq]], [[Resolution|resolution]] 2.92&Aring;' scene=''>

<table><tr><td colspan='2'>[[5hvq]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HVQ OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5HVQ FirstGlance]. <br>

</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2.923&#8491;</td></tr>

<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr>

<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5hvq FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hvq OCA], [https://pdbe.org/5hvq PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5hvq RCSB], [https://www.ebi.ac.uk/pdbsum/5hvq PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5hvq ProSAT]</span></td></tr>

[https://www.uniprot.org/uniprot/NSE3_HUMAN NSE3_HUMAN] Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest.<ref>PMID:20864041</ref>  

[[Category: Homo sapiens]]

[[Category: Large Structures]]

[[Category: Aitkenhead H]]

[[Category: Cho HJ]]

[[Category: Cooper CDO]]

[[Category: Gileadi O]]

[[Category: Newman JA]]

[[Category: Oppermann UCT]]

[[Category: Osman R]]

[[Category: Roos AK]]