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<SX load='5an9' size='340' side='right' viewer='molstar' caption='[[5an9]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
<SX load='5an9' size='340' side='right' viewer='molstar' caption='[[5an9]], [[Resolution|resolution]] 3.30&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5an9]] is a 11 chain structure with sequence from [http://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AN9 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AN9 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5an9]] is a 10 chain structure with sequence from [https://en.wikipedia.org/wiki/Dictyostelium_discoideum Dictyostelium discoideum] and [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AN9 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AN9 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5anb|5anb]], [[5anc|5anc]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 3.3&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5an9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5an9 OCA], [http://pdbe.org/5an9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5an9 RCSB], [http://www.ebi.ac.uk/pdbsum/5an9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5an9 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5an9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5an9 OCA], [https://pdbe.org/5an9 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5an9 RCSB], [https://www.ebi.ac.uk/pdbsum/5an9 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5an9 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
[[http://www.uniprot.org/uniprot/SBDS_HUMAN SBDS_HUMAN]] Idiopathic aplastic anemia;Shwachman-Diamond syndrome. The disease is caused by mutations affecting the gene represented in this entry.<ref>PMID:21536732</ref> <ref>PMID:12496757</ref> 
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/RLA0_DICDI RLA0_DICDI]] Ribosomal protein P0 is the functional equivalent of E.coli protein L10. [[http://www.uniprot.org/uniprot/IF6_DICDI IF6_DICDI]] Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis. [[http://www.uniprot.org/uniprot/RL40_DICDI RL40_DICDI]] Ubiquitin: exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-48-linked is involved in protein degradation via the proteasome. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity).  60S ribosomal protein L40: component of the 60S subunit of the ribosome. [[http://www.uniprot.org/uniprot/RL3_DICDI RL3_DICDI]] The L3 protein is a component of the large subunit of cytoplasmic ribosomes. [[http://www.uniprot.org/uniprot/SBDS_HUMAN SBDS_HUMAN]] Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFTUD1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation.<ref>PMID:17643419</ref> <ref>PMID:19602484</ref> <ref>PMID:19759903</ref> <ref>PMID:21536732</ref> 
[https://www.uniprot.org/uniprot/RL3_DICDI RL3_DICDI] The L3 protein is a component of the large subunit of cytoplasmic ribosomes.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
*[[Eukaryotic initiation factor 3D structures|Eukaryotic initiation factor 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Ribosome 3D structures|Ribosome 3D structures]]
*[[Shwachman-Bodian-Diamond Syndrome Protein|Shwachman-Bodian-Diamond Syndrome Protein]]
== References ==
== References ==
<references/>
<references/>
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[[Category: Dictyostelium discoideum]]
[[Category: Dictyostelium discoideum]]
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Churcher, M]]
[[Category: Churcher M]]
[[Category: Giudice, E]]
[[Category: Giudice E]]
[[Category: Hilcenko, C]]
[[Category: Hilcenko C]]
[[Category: Jin, L]]
[[Category: Jin L]]
[[Category: Kay, R R]]
[[Category: Kay RR]]
[[Category: Traynor, D]]
[[Category: Traynor D]]
[[Category: Warren, A J]]
[[Category: Warren AJ]]
[[Category: Weis, F]]
[[Category: Weis F]]
[[Category: Wong, C C]]
[[Category: Wong CC]]
[[Category: Efl1]]
[[Category: Gtpase]]
[[Category: Ribosome biogenesis]]
[[Category: Ribosomopathy]]
[[Category: Translation]]

Latest revision as of 14:42, 9 May 2024

Mechanism of eIF6 release from the nascent 60S ribosomal subunitMechanism of eIF6 release from the nascent 60S ribosomal subunit

5an9, resolution 3.30Å

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