5ak7: Difference between revisions

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==Structure of wt Porphyromonas gingivalis peptidylarginine deiminase==
==Structure of wt Porphyromonas gingivalis peptidylarginine deiminase==
<StructureSection load='5ak7' size='340' side='right' caption='[[5ak7]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
<StructureSection load='5ak7' size='340' side='right'caption='[[5ak7]], [[Resolution|resolution]] 1.46&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5ak7]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK7 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5AK7 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5ak7]] is a 1 chain structure with sequence from [https://en.wikipedia.org/wiki/Porphyromonas_gingivalis Porphyromonas gingivalis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5AK7 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5AK7 FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 1.46&#8491;</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5ak8|5ak8]]</td></tr>
<tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=ALA:ALANINE'>ALA</scene>, <scene name='pdbligand=ARG:ARGININE'>ARG</scene>, <scene name='pdbligand=EDO:1,2-ETHANEDIOL'>EDO</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ak7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak7 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=5ak7 RCSB], [http://www.ebi.ac.uk/pdbsum/5ak7 PDBsum]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5ak7 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ak7 OCA], [https://pdbe.org/5ak7 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5ak7 RCSB], [https://www.ebi.ac.uk/pdbsum/5ak7 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5ak7 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/PAD_PORGI PAD_PORGI]] Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth.<ref>PMID:10377098</ref>
[https://www.uniprot.org/uniprot/PAD_PORGI PAD_PORGI] Deiminates the guanidino group of C-terminal arginine residues on a variety of peptides, including the vasoregulatory peptide-hormone bradykinin, to yield ammonia and a citrulline residue. May promote the growth of the pathogen in the periodontal pocket by producing ammonia, ammonia having a protective effect during acidic cleaning cycles in the mouth.<ref>PMID:10377098</ref>  
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
<div class="pdbe-citations 5ak7" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Burgess-Brown, N]]
[[Category: Large Structures]]
[[Category: Kiyani, W]]
[[Category: Porphyromonas gingivalis]]
[[Category: Kopec, J]]
[[Category: Burgess-Brown N]]
[[Category: Montgomery, A]]
[[Category: Kiyani W]]
[[Category: Nowak, R]]
[[Category: Kopec J]]
[[Category: Shrestha, L]]
[[Category: Montgomery A]]
[[Category: Venables, P J]]
[[Category: Nowak R]]
[[Category: Yue, W W]]
[[Category: Shrestha L]]
[[Category: Hydrolase]]
[[Category: Venables PJ]]
[[Category: Ppad]]
[[Category: Yue WW]]

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