5a79: Difference between revisions

New page: '''Unreleased structure''' The entry 5a79 is ON HOLD until sometime in the future Authors: Clare, D.K., Pechnikova, E., Skurat, E., Makarov, V., Sokolova, O.S., Solovyev, A.G., V Orlova...
 
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'''Unreleased structure'''


The entry 5a79 is ON HOLD  until sometime in the future
==Novel inter-subunit contacts in Barley Stripe Mosaic Virus revealed by cryo-EM==
<SX load='5a79' size='340' side='right' viewer='molstar' caption='[[5a79]], [[Resolution|resolution]] 4.10&Aring;' scene=''>
== Structural highlights ==
<table><tr><td colspan='2'>[[5a79]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Barley_stripe_mosaic_virus Barley stripe mosaic virus] and [https://en.wikipedia.org/wiki/Tobacco_mosaic_virus_strain_OM Tobacco mosaic virus strain OM]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A79 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A79 FirstGlance]. <br>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 4.1&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a79 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a79 OCA], [https://pdbe.org/5a79 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a79 RCSB], [https://www.ebi.ac.uk/pdbsum/5a79 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a79 ProSAT]</span></td></tr>
</table>
== Function ==
[https://www.uniprot.org/uniprot/CAPSD_BSMV CAPSD_BSMV] Capsid protein self-assembles to form rod-shaped virions about 25 nm in diameter with a central canal enclosing the viral genomic RNA.
<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
Barley stripe mosaic virus (BSMV, genus Hordeivirus) is a rod-shaped single-stranded RNA virus similar to viruses of the structurally characterized and well-studied genus Tobamovirus. Here we report the first high-resolution structure of BSMV at 4.1 A obtained by cryo-electron microscopy. We discovered that BSMV forms two types of virion that differ in the number of coat protein (CP) subunits per turn and interactions between the CP subunits. While BSMV and tobacco mosaic virus CP subunits have a similar fold and interact with RNA using conserved residues, the axial contacts between the CP of these two viral groups are considerably different. BSMV CP subunits lack substantial axial contacts and are held together by a previously unobserved lateral contact formed at the virion surface via an interacting loop, which protrudes from the CP hydrophobic core to the adjacent CP subunit. These data provide an insight into diversity in structural organization of helical viruses.


Authors: Clare, D.K., Pechnikova, E., Skurat, E., Makarov, V., Sokolova, O.S., Solovyev, A.G., V Orlova, E.
Novel Inter-Subunit Contacts in Barley Stripe Mosaic Virus Revealed by Cryo-Electron Microscopy.,Clare DK, Pechnikova EV, Skurat EV, Makarov VV, Sokolova OS, Solovyev AG, Orlova EV Structure. 2015 Aug 13. pii: S0969-2126(15)00287-7. doi:, 10.1016/j.str.2015.06.028. PMID:26278173<ref>PMID:26278173</ref>


Description: Novel inter-subunit contacts in Barley Stripe Mosaic Virus revealed by cryo-EM
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
[[Category: Unreleased Structures]]
</div>
[[Category: Skurat, E]]
<div class="pdbe-citations 5a79" style="background-color:#fffaf0;"></div>
[[Category: Solovyev, A.G]]
 
[[Category: V Orlova, E]]
==See Also==
[[Category: Clare, D.K]]
*[[Tobacco Mosaic Virus|Tobacco Mosaic Virus]]
[[Category: Pechnikova, E]]
*[[Virus coat proteins 3D structures|Virus coat proteins 3D structures]]
[[Category: Sokolova, O.S]]
== References ==
[[Category: Makarov, V]]
<references/>
__TOC__
</SX>
[[Category: Barley stripe mosaic virus]]
[[Category: Large Structures]]
[[Category: Tobacco mosaic virus strain OM]]
[[Category: Clare DK]]
[[Category: Makarov V]]
[[Category: Pechnikova E]]
[[Category: Skurat E]]
[[Category: Sokolova OS]]
[[Category: Solovyev AG]]
[[Category: V Orlova E]]

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