5a36: Difference between revisions

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<StructureSection load='5a36' size='340' side='right'caption='[[5a36]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
<StructureSection load='5a36' size='340' side='right'caption='[[5a36]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
<table><tr><td colspan='2'>[[5a36]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A36 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5A36 FirstGlance]. <br>
<table><tr><td colspan='2'>[[5a36]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A36 OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A36 FirstGlance]. <br>
</td></tr><tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[5a37|5a37]], [[5a38|5a38]]</td></tr>
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 2&#8491;</td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a36 OCA], [http://pdbe.org/5a36 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5a36 RCSB], [http://www.ebi.ac.uk/pdbsum/5a36 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5a36 ProSAT]</span></td></tr>
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a36 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a36 OCA], [https://pdbe.org/5a36 PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a36 RCSB], [https://www.ebi.ac.uk/pdbsum/5a36 PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a36 ProSAT]</span></td></tr>
</table>
</table>
== Disease ==
== Disease ==
[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[http://omim.org/entry/612158 612158]]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>
[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] Defects in ACTN2 are the cause of cardiomyopathy dilated type 1AA (CMD1AA) [MIM:[https://omim.org/entry/612158 612158]. Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death.<ref>PMID:14567970</ref>  
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN]] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.  
[https://www.uniprot.org/uniprot/ACTN2_HUMAN ACTN2_HUMAN] F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein.
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<div style="background-color:#fffaf0;">
== Publication Abstract from PubMed ==
== Publication Abstract from PubMed ==
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__TOC__
__TOC__
</StructureSection>
</StructureSection>
[[Category: Human]]
[[Category: Homo sapiens]]
[[Category: Large Structures]]
[[Category: Large Structures]]
[[Category: Edwards, T A]]
[[Category: Edwards TA]]
[[Category: Haywood, N J]]
[[Category: Haywood NJ]]
[[Category: Peckham, M]]
[[Category: Peckham M]]
[[Category: Shuping, Y]]
[[Category: Shuping Y]]
[[Category: Trinh, C H]]
[[Category: Trinh CH]]
[[Category: Wolny, M]]
[[Category: Wolny M]]
[[Category: Structural protein]]

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