5a1v: Difference between revisions
New page: '''Unreleased structure''' The entry 5a1v is ON HOLD Authors: Dodonova, S.O., Diestelkoetter-Bachert, P., von Appen, A., Hagen, W.J.H., Beck, R., Beck, M., Wieland, F., Briggs, J.A.G. ... |
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The | ==The structure of the COPI coat linkage I== | ||
<SX load='5a1v' size='340' side='right' viewer='molstar' caption='[[5a1v]], [[Resolution|resolution]] 21.00Å' scene=''> | |||
== Structural highlights == | |||
<table><tr><td colspan='2'>[[5a1v]] is a 26 chain structure with sequence from [https://en.wikipedia.org/wiki/Mus_musculus Mus musculus] and [https://en.wikipedia.org/wiki/Saccharomyces_cerevisiae Saccharomyces cerevisiae]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5A1V OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=5A1V FirstGlance]. <br> | |||
</td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 21Å</td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=5a1v FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5a1v OCA], [https://pdbe.org/5a1v PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=5a1v RCSB], [https://www.ebi.ac.uk/pdbsum/5a1v PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=5a1v ProSAT]</span></td></tr> | |||
</table> | |||
== Function == | |||
[https://www.uniprot.org/uniprot/ARF1_YEAST ARF1_YEAST] GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus. Recruits polyadenylate-binding protein PAB1 to COPI vesicles, and this is required for correct localization of the asymmetrically distributed ASH1 mRNA.<ref>PMID:15356266</ref> | |||
<div style="background-color:#fffaf0;"> | |||
== Publication Abstract from PubMed == | |||
Transport of material within cells is mediated by trafficking vesicles that bud from one cellular compartment and fuse with another. Formation of a trafficking vesicle is driven by membrane coats that localize cargo and polymerize into cages to bend the membrane. Although extensive structural information is available for components of these coats, the heterogeneity of trafficking vesicles has prevented an understanding of how complete membrane coats assemble on the membrane. We combined cryo-electron tomography, subtomogram averaging, and cross-linking mass spectrometry to derive a complete model of the assembled coat protein complex I (COPI) coat involved in traffic between the Golgi and the endoplasmic reticulum. The highly interconnected COPI coat structure contradicted the current "adaptor-and-cage" understanding of coated vesicle formation. | |||
VESICULAR TRANSPORT. A structure of the COPI coat and the role of coat proteins in membrane vesicle assembly.,Dodonova SO, Diestelkoetter-Bachert P, von Appen A, Hagen WJ, Beck R, Beck M, Wieland F, Briggs JA Science. 2015 Jul 10;349(6244):195-8. doi: 10.1126/science.aab1121. PMID:26160949<ref>PMID:26160949</ref> | |||
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |||
[[Category: | </div> | ||
[[Category: | <div class="pdbe-citations 5a1v" style="background-color:#fffaf0;"></div> | ||
[[Category: | |||
[[Category: | ==See Also== | ||
[[Category: | *[[Coatomer 3D structures|Coatomer 3D structures]] | ||
[[Category: | == References == | ||
[[Category: Diestelkoetter-Bachert | <references/> | ||
[[Category: Wieland | __TOC__ | ||
[[Category: | </SX> | ||
[[Category: Large Structures]] | |||
[[Category: Mus musculus]] | |||
[[Category: Saccharomyces cerevisiae]] | |||
[[Category: Beck M]] | |||
[[Category: Beck R]] | |||
[[Category: Briggs JAG]] | |||
[[Category: Diestelkoetter-Bachert P]] | |||
[[Category: Dodonova SO]] | |||
[[Category: Hagen WJH]] | |||
[[Category: Wieland F]] | |||
[[Category: Von Appen A]] | |||