4uwa: Difference between revisions
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==Structure of the ryanodine receptor at resolution of 6.1 A in closed state== | ==Structure of the ryanodine receptor at resolution of 6.1 A in closed state== | ||
< | <SX load='4uwa' size='340' side='right' viewer='molstar' caption='[[4uwa]], [[Resolution|resolution]] 6.10Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4uwa]] is a 4 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4uwa]] is a 4 chain structure with sequence from [https://en.wikipedia.org/wiki/Oryctolagus_cuniculus Oryctolagus cuniculus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4UWA OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4UWA FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">Electron Microscopy, [[Resolution|Resolution]] 6.1Å</td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4uwa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4uwa OCA], [https://pdbe.org/4uwa PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4uwa RCSB], [https://www.ebi.ac.uk/pdbsum/4uwa PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4uwa ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/RYR1_RABIT RYR1_RABIT] Calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytoplasm and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis (By similarity).<ref>PMID:10388749</ref> <ref>PMID:22036948</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4uwa" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4uwa" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Ryanodine receptor 3D structures|Ryanodine receptor 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</ | </SX> | ||
[[Category: Large Structures]] | |||
[[Category: Oryctolagus cuniculus]] | [[Category: Oryctolagus cuniculus]] | ||
[[Category: Aebersold | [[Category: Aebersold R]] | ||
[[Category: Efremov | [[Category: Efremov RG]] | ||
[[Category: Leitner | [[Category: Leitner A]] | ||
[[Category: Raunser | [[Category: Raunser S]] | ||