4usd: Difference between revisions
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<StructureSection load='4usd' size='340' side='right'caption='[[4usd]], [[Resolution|resolution]] 3.05Å' scene=''> | <StructureSection load='4usd' size='340' side='right'caption='[[4usd]], [[Resolution|resolution]] 3.05Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
<table><tr><td colspan='2'>[[4usd]] is a 2 chain structure with sequence from [ | <table><tr><td colspan='2'>[[4usd]] is a 2 chain structure with sequence from [https://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4USD OCA]. For a <b>guided tour on the structure components</b> use [https://proteopedia.org/fgij/fg.htm?mol=4USD FirstGlance]. <br> | ||
</td></tr><tr id=' | </td></tr><tr id='method'><td class="sblockLbl"><b>[[Empirical_models|Method:]]</b></td><td class="sblockDat" id="methodDat">X-ray diffraction, [[Resolution|Resolution]] 3.05Å</td></tr> | ||
<tr id=' | <tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat" id="ligandDat"><scene name='pdbligand=R09:4-{5-(6-METHOXYNAPHTHALEN-2-YL)-1-METHYL-2-[2-METHYL-4-(METHYLSULFONYL)PHENYL]-1H-IMIDAZOL-4-YL}PYRIDINE'>R09</scene></td></tr> | ||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[https://proteopedia.org/fgij/fg.htm?mol=4usd FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4usd OCA], [https://pdbe.org/4usd PDBe], [https://www.rcsb.org/pdb/explore.do?structureId=4usd RCSB], [https://www.ebi.ac.uk/pdbsum/4usd PDBsum], [https://prosat.h-its.org/prosat/prosatexe?pdbcode=4usd ProSAT]</span></td></tr> | |||
<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[ | |||
</table> | </table> | ||
== Disease == | == Disease == | ||
[ | [https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] The disease may be caused by mutations affecting the gene represented in this entry.<ref>PMID:16175573</ref> | ||
== Function == | == Function == | ||
[ | [https://www.uniprot.org/uniprot/STK10_HUMAN STK10_HUMAN] Serine/threonine-protein kinase involved in regulation of lymphocyte migration. Phosphorylates MSN, and possibly PLK1. Involved in regulation of lymphocyte migration by mediating phosphorylation of ERM proteins such as MSN. Acts as a negative regulator of MAP3K1/MEKK1. May also act as a cell cycle regulator by acting as a polo kinase kinase: mediates phosphorylation of PLK1 in vitro; however such data require additional evidences in vivo.<ref>PMID:11903060</ref> <ref>PMID:12639966</ref> <ref>PMID:19255442</ref> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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</div> | </div> | ||
<div class="pdbe-citations 4usd" style="background-color:#fffaf0;"></div> | <div class="pdbe-citations 4usd" style="background-color:#fffaf0;"></div> | ||
==See Also== | |||
*[[Serine/threonine protein kinase 3D structures|Serine/threonine protein kinase 3D structures]] | |||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: | [[Category: Homo sapiens]] | ||
[[Category: Large Structures]] | [[Category: Large Structures]] | ||
[[Category: Bountra C]] | |||
[[Category: Bountra | [[Category: Canning P]] | ||
[[Category: Canning | [[Category: Edwards AM]] | ||
[[Category: Elkins JM]] | |||
[[Category: Edwards | [[Category: Knapp S]] | ||
[[Category: Elkins | [[Category: Raynor J]] | ||
[[Category: Knapp | [[Category: Salah E]] | ||
[[Category: Raynor | [[Category: Szklarz M]] | ||
[[Category: Salah | [[Category: Von Delft F]] | ||
[[Category: Szklarz | |||
[[Category: | |||